| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 洪欣怡 | zh_TW |
| DC.creator | Shin-Yi Hung | en_US |
| dc.date.accessioned | 2005-7-24T07:39:07Z | |
| dc.date.available | 2005-7-24T07:39:07Z | |
| dc.date.issued | 2005 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=92223033 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 本論文以D-(–)-2-苯甘胺酸61 作為含有光學輔助基的起始物，經由官能基轉換與修飾後，環化生成噁嗪酮(oxazinone) 59；利用化合物59製備烯醇陰離子進行不對稱碳-碳烷化後，碳-氮烷化並合環形成化合物58，再經由各種不同的親電子基(electrophile)進行第二次烷化與氫化之後，就可以得到在α-碳上有不同取代基的六氫菸鹼酸57。 | zh_TW |
| dc.description.abstract | The synthesis of 57 is based on the chiral oxazinone 59 as a chiral glycine enolate synthon. Asymmetric alkylation of 59 with 1,4-diiodobutane, deprotection and cyclization gave the 4-phenylhexahydropyrido[2,1-c][1,4]
oxazin-1-one. Both enantiomers of pipecolic acid and 2-alkyl pipecolic acids were prepared by the epimerization or the second alkylation of 58 followed by hydrogenation. | en_US |
| DC.subject | 六氫菸鹼酸 | zh_TW |
| DC.subject | 對掌中心 | zh_TW |
| DC.subject | 鏡像異構物 | zh_TW |
| DC.subject | enantioselective | en_US |
| DC.subject | chiral center | en_US |
| DC.subject | Pipecolic acid | en_US |
| DC.title | 合成具有光學活性之六氫菸鹼酸(Pipecolic acid) | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.title | Enaantioselective Synthesis of Pipecolic Acids | en_US |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |