博碩士論文 92223038 完整後設資料紀錄

DC 欄位 語言
DC.contributor化學學系zh_TW
DC.creator王碧蓮zh_TW
DC.creatorPi-Lien Wangen_US
dc.date.accessioned2005-6-20T07:39:07Z
dc.date.available2005-6-20T07:39:07Z
dc.date.issued2005
dc.identifier.urihttp://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=92223038
dc.contributor.department化學學系zh_TW
DC.description國立中央大學zh_TW
DC.descriptionNational Central Universityen_US
dc.description.abstract近年來在環境檢測方面,科學家對於具有生物活性之微量藥物殘留在環境中的含量與流布之檢測,產生濃厚的興趣與關注,主要是由於這類殘留藥物對野生動物或水中魚類的生存產生極大的衝擊,透過食物鏈的途徑甚至可能會影響到人類的健康。這類殘留藥物主要包括止痛劑、脂質調節劑與抗生素等等。而本實驗將針對以下六種常見的藥物殘留物進行分析與研究:安妥明、卡巴氮平、二克氯吩鈉、異布洛芬、凱妥普洛芬與那普洛辛。 本研究的主要目的在發展一套快速、可靠、穩定的分析方法,研究這些藥物殘留物在國內水環境中的流布與含量,首先以液相層析質譜儀在不同的沖提流速下進行分離後,再搭配三種不同的游離源尋找最佳化的層析分離法與游離化條件,並且搭配良好的固相萃取法,可以達到濃縮與去干擾的目的。由實驗結果發現以LC沖提流速為0.2 ml/min,搭配ESI游離介面進行二次質譜法可得到較佳的感度,並且在最佳化的層析分離方法與游離條件之下,偵測極限可達到0.4~80 ng/L,檢量線r2值均大於0.994。並且搭配可靠的前處理方法對於民生廢污水與河流水樣進行檢測,檢測結果發現在民生廢污水與河流水樣當中皆可偵測到這六種藥物殘留物的存在,濃度最高可達963 ng/L,回收率為45~117%,RSD值均小於8.5%。zh_TW
dc.description.abstractA method for the determination of selected pharmaceutical residues (clofibric acid, ibuprofen, carbamazepine, naproxen, ketoprofen and diclofenac) in various water samples was developed and validated. The contents of pharmaceutical residues in water samples were extracted by Oasis HLB solid-phase extraction (SPE). The analytes were then identified and quantitated by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Three ionization techniques, electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI), were tested, while ESI in negative and positive modes (for carbamazepine) proved to be the most sensitive ionization method. Limits of quantitation (LOQ) were established between 2.0 to 200 ng/L in 250 mL of water sample. Intrabatch and interbatch precision with their accuracy at two concentration levels were also investigated. The selected analytes were detected in concentrations from 24 to 963 ng/L in wastewater treatment plant effluent and river water samples.en_US
DC.subject安妥明zh_TW
DC.subject卡巴氮平zh_TW
DC.subject液相層析串聯質譜技術zh_TW
DC.subject那普洛辛zh_TW
DC.subject凱妥普洛芬zh_TW
DC.subject異布洛芬zh_TW
DC.subject二克氯吩鈉zh_TW
DC.subject固相萃取法zh_TW
DC.subjectibuprofenen_US
DC.subjectLC-MS/MSen_US
DC.subjectdiclofenacen_US
DC.subjectketoprofenen_US
DC.subjectnaproxenen_US
DC.subjectclofibric aciden_US
DC.subjectcarbamazepineen_US
DC.subjectsolid phase extractionen_US
DC.title利用液相層析串聯質譜技術檢測水環境中藥物殘留物之方法開發與應用zh_TW
dc.language.isozh-TWzh-TW
DC.titleDetermination of pharmaceutical resides in waters by solid phase extraction with liquid chromatography-tandem mass spectrometryen_US
DC.type博碩士論文zh_TW
DC.typethesisen_US
DC.publisherNational Central Universityen_US

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