| DC 欄位 |
值 |
語言 |
| DC.contributor | 生物物理研究所 | zh_TW |
| DC.creator | 湯智超 | zh_TW |
| DC.creator | Chih-Chao Tang | en_US |
| dc.date.accessioned | 2007-7-11T07:39:07Z | |
| dc.date.available | 2007-7-11T07:39:07Z | |
| dc.date.issued | 2007 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:444/thesis/view_etd.asp?URN=942210003 | |
| dc.contributor.department | 生物物理研究所 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 我們提出了一個理論模型來描述配體-受體叢集的生命期
T( f , Nt )與叢集大小Nt、外力F 的關係，這裡f = F/Nt 為每
一配體-受體對所受之力。此叢集是由Nt 個平行的配體受體
對所組成。由反應速率方程式我們找到一個叢集的特徵力
fc ，我們由不同外力下的蒙地卡羅模擬發現(1)當f >fc 時,
叢集生命期與叢集大小無關。這是由於在反應速率方程式
中，鍵結數目在叢集中所佔比例的衰變與叢集大小無關，而
與f 有關。(2)當f =fc 時，生命期與叢集大小有冪次關係
lnT~lnNt。為了解釋此結果我們引入等效自由能G，則一叢
集的斷裂過程可以用一假想粒子在位能G 下的運動來描
述。在f =fc 時，G 有個反曲點，且叢集生命期大多都花在反
曲點附近的區域上，由標度分析可得lnT~lnNt。(3)當f | zh_TW | |
| dc.description.abstract | =＂＂ we=＂＂ present=＂＂ a=＂＂ theoretical=＂＂ model=＂＂ to=＂＂ study=＂＂ the=＂＂ lifetime=＂＂ t(nt,=＂＂ f)=＂＂ of=＂＂ an=＂＂ adhesion
=＂＂ cluster=＂＂ under=＂＂ external=＂＂ force=＂＂ f,=＂＂ where=＂＂ nt=＂＂ is=＂＂ size=＂＂ and=＂＂ f=＂F/Nt.＂ the
=＂＂ composed=＂＂ parallel=＂＂ ligand-receptor=＂＂ pairs.=＂＂ find=＂＂ character-
=＂＂ istic=＂＂ fc=＂＂ predicted=＂＂ by=＂＂ rate=＂＂ equation.=＂＂ monte=＂＂ carlo=＂＂ simulation,=＂＂ we
=＂＂ show=＂＂ (i)=＂＂ when=＂＂> fc, T is independent of Nt. This can be explained by the
rate equation which predicts that the fraction of connected ligand-receptor
pairs nb(t) depends on f, but not on Nt. (ii)When f = fc, lnT(Nt, f) ∼ lnNt.
To explain the result we construct the effective free energy G and treat the
force pulling process as a particle moving under G in Nb space. G(f = fc)
has a flat region where the particle spends most of its lifetime to cross it.
By estimating the width of the flat region with dimensional analysis, we find
lnT(Nt, f) ∼ lnNt. (iii) When f < fc regime, lnT(Nt, f) ∼ Nt because
G(f < fc) has a barrier with barrier height ∼ Nt and lifetime T comes from
the barrier crossing time of the particle, as a result lnT(Nt, f) ∼ Nt. Finally
we show that the above three relations exist as long as the rebinding and
unbinding rates are functions of f and nb. | en_US |
| DC.subject | 叢集 | zh_TW |
| DC.subject | 黏著 | zh_TW |
| DC.subject | 強度 | zh_TW |
| DC.subject | cluster | en_US |
| DC.subject | adhesion | en_US |
| DC.title | 兩板間黏著叢集的強度 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.title | The strength of an adhesion cluster between two plates | en_US |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |