| dc.description.abstract | Low level light therapy (LLLT) is using the LASER or LED light source to apply in medical fields, which can treat disease or change the cell physical function. Although the hair loss is not a severely disease, it affects the outlook of people. In 2007, a laser comb design (wavelength 660nm) was approved by the FDA for the treatment of hair loss in males with androgenetic alopecia. The LED has the advantage of cheap and low power, therefore, we want to compare the therapeutic effect between the LED and LASER light source.
We designed a LLLT therapeutic platform which can compare treatment effect between different light sources. The light source of platform can be from LED and LASER light. After diffuser design, the output power can be uniformed and reach to more than 90% uniformity. By the design platform, we can compare the hair growth effect of mice between the LED and LASER light source. We can also compare the hair growth effect of LLLT in different wavelength, such as control (no light application), white LED (530 nm), red LED (660 nm), infra-red LED (808 nm), red LASER (660 nm) and infra-red LASER (808 nm).
We underwent three LLLT experiments of mice hair growth. All the mice was the inbred strain of C57BL/6JNarl(also called B6 mice). As the result, there were similar effect of mice hair growth between the LED (wavelength 660 nm) and LASER light (wavelength 660 nm). In the observation of skin tissues biopsy on fluorescence microscopy, there were similar postive findings of CD34 and Ki67 in LLLT with the wavelength 660 nm(ether from LED or LASER light source). This means that LLLT in wavelength 660nm could promote the hair follicle from telogen phase into anagen phase.
As for safty, the temperature was not increased in our experiment during LLLT and could not make burn injury of skin. In other words, the safty was accetable for the increase of temperature.
From this design platform, we can apply this LLLT design on other medical field research. We can compare the therapeutic effect between the LASER and LED light source in different wavelength with the same output power. | en_US |