| 摘要(英) |
Methamphetamine (Methamphetamine, MA, called methamphetamine in Chinese) is currently the top three drug abusers in China. In the subsequent process of detoxification, there will be many withdrawal symptoms, such as listlessness, depression, restlessness, restlessness, etc. It is quite easy to relapse in the future process of detoxification. Studies have shown that drug abusers are prompted by VR neutral and drug-related environments, and the brain Gamma waves produce abnormalities in the medial prefrontal cortex/orbitofrontal cortex (MPFC / OFC) and dorsolateral prefrontal cortex (DLPFC) , And long-term use of drugs affect the central nervous system, and then cause abnormal brain function, such as psychosis, delusions and violent behavior, and observe abnormal brain wave frequency bands, but also cause arrhythmia and abnormalities of the autonomic nervous system. There are also several similar studies that explore whether the neutral VR environment and related drug environmental stimuli can actually cause stimulus responses, and propose that Gamma waves are related to the reward mechanism of the cerebral cortex. Under the stimulation of related drug environments, it is obviously induced Mood swings. Most of the research directions are the comparison of the neutral environment and the drug environment. Therefore, this research focuses on the analysis of the VR drug-related environment, observing the changes of stimulation of different intensities, and the electrophysiological signal between normal and drug addicts. Differences, and study the existence of their relevance, and the physiological significance that can be exhibited.
This study collected cases from Kaohsiung Chang Gung Memorial Hospital and Keelung Chang Gung Memorial Hospital in the Department of Psychiatry. There were 51 people in total, but currently only 26 people have undergone EEG experiments. There are 16 people in the experimental group (drug abusers) and 10 people in the control group (normal people). Use Virtual Reality (VR) to create a realistic KTV scene, divide four different stimulus intensities during the game, to stimulate the experimental group and the control group and collect FCZ, CZ, PZ, C3, C4 Channel brainwave data and ECG information for analysis and comparison. Research method We used Matlab R2019a SPM12 to process brain wave data, and applied signal processing methods (Wavelet and Hilbert-Huang Transform) to analyze the difference between the experimental group and the control group. ECG conducts HRV analysis to obtain some indicators for discussion, and analyzes the correlation between EEG and ECG. The results of the study showed that after watching the VR scenes individually in the patient group and the healthy group, under the four stages of different stimulation conditions, compared with the healthy group, the patient group found that the Alpha wave and Beta wave increased significantly under the fourth stage of stimulation. high. There is no significant difference between the two groups. The reason may be that there is only a single stimulus VR environment, and the content provided by the VR game content is only to cause a desire for drugs. To confirm the difference between the patient group and the healthy group , Must rely on the results of the post-test experiment. The analysis of HRV is in line with many previous related studies. The Poincaré diagram′s nonlinear analysis method is correlated with the frequency domain analysis method. In the discovery of LF and sympathetic nerves, we have found a set of test standards that may be treated later . Finally, the findings of EEG and ECG let us know that there is a correlation between them, and it also provides a major direction for follow-up research. However, because the number of people in this study is currently too small, it is expected that more data will be added in the future to improve the accuracy of the experiment, which can help more research on other substance addictions and provide help for the treatment of such brain diseases. |
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