多光譜光照治療結合皮膚阻抗監測 穿戴式裝置之開發

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簡翌安(Yi-An Jian) 查詢紙本館藏

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機械工程學系

論文名稱

多光譜光照治療結合皮膚阻抗監測穿戴式裝置之開發
(Multispectral Light Therapy Combined with Skin Impedance Monitoring Development of Wearable Devices)

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至系統瀏覽論文 (2030-1-16以後開放)

摘要(中)

近年來，穿戴式電子裝置在健康監測領域的應用愈加廣泛，這些裝置能即時偵測使用者的健康狀況，並通過有線或無線方式將數據傳送至接收裝置，必要時再傳至雲端進行處理，以達成即時健康監控的目的。同時，智慧型傷口敷料的發展亦引起了越來越多的關注。傳統的智慧型傷口敷料主要依賴於軟性印刷電路板(FPC)，然而，這類技術雖適合大規模生產，但在面對個別患者需求的客製化生產時，成本將大幅增加。積層製造技術因其能夠列印複雜外型，特別適合用於針對不規則形狀傷口的智慧型敷料客製化生產。

本研究基於積層製造技術，使用高解析度光固化成形技術製作了一款雙層智慧穿戴式繃帶。該貼片結構包含生物電阻抗電極電路和 3x3 多光譜光療模組電路，其電路直接列印於撓性基板上，並將發光二極體嵌入基板中，從而減少裝置整體厚度並提高電路穩定性。導電電路透過直接墨水書寫技術列印導電墨水，並在固化後，將兩片撓性基板利用基板材料作為黏著劑進行接合，最終再以導電墨水連接導通接合後的雙層基板電路。此外，為了均勻擴散多光譜光療模組的光線和保護發光二極體，防止外部環境對電路和電子元件的影響，研究中使用了二氧化矽與聚二甲基矽氧烷混合的光擴散層進行封裝。

該穿戴式繃帶可透過微處理器結合低功耗藍牙技術，以無線方式由手機 APP 控制其生物阻抗測量和多光譜光療模組的操作，讓使用者能夠迅速獲取並管理健康資訊。為驗證貼片的可靠性，本研究將進行阻抗量測分析、不同彎曲條件下的電路穩定性測試、表面溫度穩定性測試及光擴散層性能評估。

摘要(英)

In recent years, wearable electronic devices have found increasingly broad applications in health monitoring. These devices can detect the user’s health status in real time and transmit data to receiving devices via wired or wireless communication. When necessary, the data can be sent to the cloud for processing, enabling real-time health monitoring. Simultaneously, the development of smart wound dressings has garnered growing attention. Traditional smart wounddressings primarily rely on flexible printed circuit boards (FPC). While these technologies are suitable for mass production, they significantly increase costs when customized for individual patient needs. Additive manufacturing, with its ability to fabricate complex shapes, is particularly well-suited for producing custom smart dressings tailored to irregularly shaped wounds.

This study utilizes additive manufacturing to develop a dual-layer smart wearable bandage using high-resolution photopolymerization technology. The patch structure includes bioimpedance electrode circuits and multispectral phototherapy module circuits. The circuits are directly printed onto flexible substrates, with light-emitting diodes (LEDs) embedded in the substrate, reducing the overall thickness of the device and enhancing circuit stability. Conductive circuits are printed using direct ink writing (DIW) of conductive ink, and after curing, the two flexible substrates are bonded using the substrate material as an adhesive. The bonded double-layer substrate circuits are then electrically connected with conductive ink.Furthermore, to evenly diffuse light from the multispectral phototherapy module and protect the LEDs from external environmental impacts, a light-diffusion encapsulation layer, composed of a mixture of silicon dioxide and polydimethylsiloxane (PDMS), is employed.

The wearable bandage integrates a microcontroller and low-power Bluetooth technology, enabling wireless control of bioimpedance measurement and the operation of the multispectral phototherapy module via a smartphone app. This allows users to quickly access and manage health information. To validate the patch’s reliability, the study will conduct impedance measurement analysis, circuit stability tests under different bending conditions, surface temperature stability tests, and performance evaluations of the light-diffusion layer.

關鍵字(中)

★ 積層製造
★ 軟性印刷電路板
★ 醫療穿戴式裝置
★ 生物電阻抗
★ 發光二極體

關鍵字(英)

★ Additive Manufacturing
★ Flexible Printed Circuit Board
★ Medical Wearable Devices
★ Bioelectrical Impedance
★ Light Emitting Diode

論文目次

摘要 i
ABSTRACT ii
致謝 iv
目錄 ivvi
圖目錄 vii
表目錄 xii
第一章緒論 1
1-1 前言 1
1-2 文獻回顧 2
1-3 團隊先前研究 14
1-4 研究動機與目的 15
1-5 論文架構 17
第二章研究與理論說明 18
2-1 印刷電路板簡介 18
2-2 直接墨水書寫技術簡介 20
2-3 光生物調節療法 21
2-4 脈衝寬度調變 23
2-5 生物電阻抗分析 24
2-6 低功耗藍牙無線通訊技術 25
2-7 醫療器材電氣設備和生物相容性規範 25
第三章系統架構與研究方法 30
3-1 雙層智慧穿戴式繃帶系統架構和製作 30
3-2 雙層電路製作流程 37
3-3 多光譜光照模組 40
3-4 生物電阻抗量測模組 45
3-5 遠端傳輸架構 50
3-6 封裝層光擴散性測試 56
3-7 彎曲電路穩定性測試 63
3-8 表面工作溫度測試 64
第四章實驗結果與討論 66
4-1 雙層智慧穿戴式繃帶製作結果 66
4-2 多光譜光照模組功能測試 68
4-3 封裝層的光散射影響 72
4-4 生物電阻抗量測結果 81
4-5 彎曲電路穩定性測試結果 83
4-6 表面工作溫度測試結果 85
第五章結論與未來展望 87
5-1 結論 87
5-2 未來展望 87
參考文獻 89

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指導教授

廖昭仰(Chao-Yaug Liao)

審核日期

2025-1-17

推文