博碩士論文 111324026 詳細資訊




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姓名 林意萱(Yi-Shiuan Lin)  查詢紙本館藏   畢業系所 化學工程與材料工程學系
論文名稱 氯胺酮對仿生物膜與神經遞質釋放之影響
(Effects of Ketamine on Biomimetic Membranes and Neurotransmitter Release)
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檔案 [Endnote RIS 格式]    [Bibtex 格式]    [相關文章]   [文章引用]   [完整記錄]   [館藏目錄]   至系統瀏覽論文 (2029-9-11以後開放)
摘要(中) 本研究重點關注氯胺酮(ketamine,俗稱K他命)對神經遞質(neurotransmitter)釋放和囊泡(vesicle)融合的影響,及其在憂鬱症治療中的應用。臨床研究顯示,氯胺酮可以快速且有效地緩解憂鬱症狀。目前的研究指出,氯胺酮的藥理治療可能與阻斷神經元(neuron)突觸間隙(synapse)中之谷氨酸(glutamic acid)的再吸收與神經元囊泡之釋放有關,但確切之作用機制仍有待釐清。因此,本研究將透過仿生脂質膜(biomimetic lipid membranes,作為神經元之細胞膜的模型系統)進行物理實驗,包括在膜融合實驗中氯胺酮是否影響融合程度釋放神經傳遞質,以及探討其原因是否為脂質膜的物理性質(脂雙層厚度和自發曲率)的改變,來進一步瞭解氯胺酮緩解憂鬱症狀的藥理機制。氯胺酮的存在對於脂雙層厚度及自發曲率並無太大變化,對於添加氯胺酮後的膜融合程度降低可能有其他原因。
摘要(英) This study focuses on the effects of ketamine on neurotransmitter release and vesicle fusion, and its application in the treatment of depression. Clinical studies show that ketamine can quickly and effectively relieve symptoms of depression. Current research points out that pharmacological treatment with ketamine may be related to blocking the reabsorption of glutamic acid and the release of neuronal vesicles in the synapse of neurons, but the exact mechanism of action Still to be clarified. Therefore, this study will conduct physical experiments through biomimetic lipid membranes (as a model system of neuronal cell membranes), including whether ketamine affects the extent of fusion and the release of neurotransmitters in membrane fusion experiments, and explore whether the reasons are. To further understand the pharmacological mechanism of ketamine in relieving depression symptoms through changes in the physical properties of lipid membranes (lipid bilayer thickness and spontaneous curvature). The presence of ketamine did not change the lipid bilayer thickness and spontaneous curvature much, and there may be other reasons for the reduced extent of membrane fusion after the addition of ketamine.
關鍵字(中) ★ 憂鬱症
★ 氯胺酮
★ 谷氨酸
★ 脂質膜
關鍵字(英) ★ Depression
★ ketamine
★ glutamate
★ lipid membrane
論文目次 摘要 I
Abstract II
誌謝 III
目錄 V
圖目錄 VIII
表目錄 XI
第一章 緒論 1
1-1簡介 1
1-2研究目的及動機 2
第二章 文獻回顧 3
2-1憂鬱症 3
2-1-1神經傳遞質(neurotransmitter) 5
2-1-2胞吐作用 8
2-2氯胺酮(ketamine) 10
2-3生物膜 13
2-4彈性性質(elastic property) 15
2-4-1彎曲模量(bending modulus) 15
2-4-2自發曲率(spontaneous curvature, C0) 16
第三章 實驗製備與儀器測量 19
3-1實驗材料 19
3-2實驗儀器 22
3-3樣品製備 23
3-3-1仿突觸囊泡膜 23
3-3-2仿神經細胞膜 25
3-3-3谷氨酸濃度標準曲線 26
3-3-4膜融合 28
3-3-5 HII phase 30
3-4儀器分析 32
3-4-1動態光散射(dynamic light scattering, DLS) 32
3-4-2螢光光譜儀(fluorescence spectrometer) 35
3-4-3 小角度X光散射(small angle x-ray scattering, SAXS) 37
3-5數據處理與分析 40
3-5-1 HII電子雲密度(HII electron density) 40
3-5-2量化自發曲率C0 44
3-5-3 脂質體(liposome)膜厚度 45
第四章 結果與討論 47
4-1仿神經細胞膜與仿突觸囊泡膜之DLS結果 47
4-2 氯胺酮對膜融合之影響 49
4-3 氯胺酮對脂質膜的結構和膜厚的影響與膜融合之關聯性 54
4-4自發曲率與膜融合之相關性 58
第五章 結論 65
參考資料 66
附錄 81
附錄一 膜融合-三獨立樣品重複實驗 81
附錄二 SAXS膜厚數據 83
附錄三 六角相擬合數據 87
參考文獻 [1]Bao, A. M. & Swaab, D. F., “The human hypothalamus in mood disorders: The HPA axis in the center”, IBRO Reports, 6, 2019, 45-53.
[2]Xu, Y., Hackett, M., Carter, G., Loo, C., Gálvez, V., Glozier, N., ... & Rodgers, A., “Effects of Low-Dose and Very Low-Dose Ketamine among Patients with Major Depression: a Systematic Review and Meta-Analysis”, International Journal of Neuropsychopharmacology, 19(4), 2016,1-15.
[3]Niciu, M. J., Kelmendi, B., & Sanacora, G., “Overview of glutamatergic
neurotransmission in the nervous system”, Pharmacology Biochemistry and
Behavior, 100(4), 2012, 656-664.
[4]Rajkowska, G., & A Stockmeier, C., “Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue”, Current drug targets, 14(11), 2013, 1225-1236.
[5]Krystal, J. H., Abdallah, C. G., Sanacora, G., Charney, D. S., & Duman, R. S., “Ketamine: A Paradigm Shift for Depression Research and Treatment”,
Neuron, 101(5), 2019, 774-778.
[6]Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J., “Brain membrane lipids in major depression and anxiety disorders”, Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1851(8), 2015, 1052-1065.
[7]Stenovec, M., Li, B., Verkhratsky, A., & Zorec, R., “Astrocytes in rapid ketamine antidepressant action”, Neuropharmacology, 173, 2020, 108158.
[8]Altamura, C. A., Mauri, M. C., Ferrara, A., Moro, A. R., D′Andrea, G., & Zamberlan, F., “Plasma and platelet excitatory amino acids in psychiatric disorders”, The American journal of psychiatry, 150(11), 1993, 1731-1733.
[9]Mitani, H., Shirayama, Y., Yamada, T., Maeda, K., Ashby Jr, C. R., & Kawahara, R., “Correlation between plasma levels of glutamate, alanine and serine with severity of depression”, Progress in neuro-psychopharmacology and biological psychiatry, 30(6), 2006, 1155-1158.
[10]Woo, H. I., Chun, M. R., Yang, J. S., Lim, S. W., Kim, M. J., Kim, S. W., ... & Lee, S. Y., “Plasma amino acid profiling in major depressive disorder treated with selective serotonin reuptake inhibitors”, CNS neuroscience & therapeutics, 21(5), 2015 417-424.
[11]Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., ... & Schatzberg, A. F., “Major depressive disorder”, Nature reviews Disease primers, 2(1), 2016, 1-20,.
[12]Fekadu, N., Shibeshi, W., & Engidawork, E., “Major depressive disorder: pathophysiology and clinical management”, J Depress Anxiety, 6(1), 2017, 255-257.
[13]Chesney, E., Goodwin, G. M., & Fazel, S., “Risks of all-cause and suicide
mortality in mental disorders: a meta-review”, World psychiatry , 13(2), 2014, 153-160.
[14]Kessler, R. C., “The Costs of Depression”, Psychiatric Clinics, 35(1), 2012, 1-14.
[15]Fava, M., & Kendler, K. S., “Major depressive disorder”, Neuron, 28(2), 2000, 335-341.
[16]Chaudhury, D., Liu, H., & Han, M. H., “Neuronal correlatesdepression”, Cellular and Molecular Life Sciences, 72, 2015, 4825-4848.
[17]Bao, A. M., Ruhé, H. G., Gao, S. F., & Swaab, D. F., “Neurotransmitters and neuropeptides in depression”, Handbook of clinical neurology, 106, 2012, 107-136.
[18]Zisook, S., Rush, A. J., Albala, A., Alpert, J., Balasubramani, G. K., Fava, M., ... & Wisniewski, S., “Factors that differentiate early vs. later onset of major depression disorder”, Psychiatry research, 129(2), 2004, 127-140.
[19]Goldman, L. S., Nielsen, N. H., Champion, H. C., & Council on Scientific Affairs, American Medical Association., “Awareness, diagnosis, and treatment of depression”, Journal of general internal medicine, 14(9), 1999, 569-580.
[20]Blier, P., “Neurotransmitter targeting in the treatment of depression”, The Journal of clinical psychiatry, 74(suppl 2), 2013, 12763.
[21]Hamon, M., & Blier, P., “Monoamine neurocircuitry in depression and strategies for new treatments”. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 45, 2013, 54-63.
[22]Hirschfeld, R. M., “History and evolution of the monoamine hypothesis of depression”, Journal of clinical psychiatry, 61(6), 2000, 4-6,.
[23]Mann, J. J., Stanley, M., McBride, P. A., & McEwen, B. S., “Increased serotonin2 and β-adrenergic receptor binding in the frontal cortices of suicide victims”, Archives of general psychiatry, 43(10), 1986, 954-959.
[24]Goddard, A. W., Ball, S. G., Martinez, J., Robinson, M. J., Yang, C. R., Russell, J. M., & Shekhar, A., “Current perspectives of the roles of the central norepinephrine system in anxiety and depression”, Depression and anxiety, 27(4), 2010, 339-350,.
[25]Vizi, E. S., “Presynaptic modulation of transmitter release via α 2-adrenoceptors: nonsynaptic interactions”, Acta Biologica Hungarica, 50, 1999, 287-295.
[26]Sánchez, C., & Hyttel, J., “Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding”, Cellular and molecular neurobiology, 19, 1999, 467-489.
[27]Sibille, E., & Lewis, D. A., “SERT-ainly involved in depression, but when?”, American Journal of Psychiatry, 163(1), 2006, 8-11.
[28]Hasenhuetl, P. S., Freissmuth, M., & Sandtner, W., “Electrogenic binding of intracellular cations defines a kinetic decision point in the transport cycle of the human serotonin transporter”, Journal of Biological Chemistry, 291(50), 2016, 25864-25876.
[29]Orrego, F., & Villanueva, S., “The chemical nature of the main central excitatory transmitter: a critical appraisal based upon release studies and synaptic vesicle localization”, Neuroscience, 56(3), 1993, 539-555.
[30]Takamori, S., “VGLUTs: ‘exciting’ times for glutamatergic research?”. Neuroscience research, 55(4), 2006, 343-351.
[31]Rizo, J., & Südhof, T. C., “The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices- guilty as charged?”, Annual review of cell and developmental biology, 28, 2012, 279-308.
[32]Montana, V., Ni, Y., Sunjara, V., Hua, X., & Parpura, V., “Vesicular glutamate transporter-dependent glutamate release from astrocytes”, Journal of Neuroscience, 24(11), 2004, 2633-2642.
[33]Fremeau Jr, R. T., Kam, K., Qureshi, T., Johnson, J., Copenhagen, D. R., Storm-Mathisen, J., ... & Edwards, R. H., “Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites”, Science, 304(5678), 2004, 1815-1819.
[34]Tsien, J. Z., Huerta, P. T., & Tonegawa, S., “The essential role of hippocampal CA1 NMDA receptor–dependent synaptic plasticity in spatial memory”, Cell, 87(7), 1996, 1327-1338.
[35]Henson, M. A., Roberts, A. C., Salimi, K., Vadlamudi, S., Hamer, R. M., Gilmore, J. H., ... & Philpot, B. D., “Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex”, Cerebral Cortex, 18(11), 2008, 2560-2573.
[36]Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K., & Südhof, T. C., “α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis”, Nature, 423(6943), 2003, 939-948.
[37]Jahn, R., & Fasshauer, D., “Molecular machines governing exocytosis of synaptic vesicles”. Nature, 490(7419), 2012, 201-207.
[38]Miller, S. L., & Yeh, H. H., “Neurotransmitters and neurotransmission in the developing and adult nervous system”, Conn′s Translational Neuroscience, 2017, 49-84.
[39]Blumenthal, R., Clague, M. J., Durell, S. R., & Epand, R. M., “Membrane fusion”, Chemical reviews, 103(1), 2003, 53-70.
[40]Jahn, R., & Südhof, T. C., “Membrane fusion and exocytosis”, Annual review of biochemistry, 68(1), 1999, 863-911.
[41]Chernomordik, L. V., & Kozlov, M. M., “Mechanics of membrane fusion”, Nature structural & molecular biology, 15(7), 2008, 675-683.
[42]Lainé, C., “Research essay Biophysical investigation of the antiviral activity of IFITM proteins”, 2020.
[43]Zanos, P., Moaddel, R., Morris, P. J., Riggs, L. M., Highland, J. N., Georgiou, P., ... & Gould, T. D., “Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms”, Pharmacological reviews, 70(3), 2018, 621-660.
[44]McEwen, B. S., “Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators”, European journal of pharmacology, 583(2-3), 2008, 174-185.
[45]Duman, R. S., Li, N., Liu, R. J., Duric, V., & Aghajanian, G., “Signaling pathways underlying the rapid antidepressant actions of ketamine”, Neuropharmacology, 62(1), 2012, 35-41.
[46]Wray, N. H., Schappi, J. M., Singh, H., Senese, N. B., & Rasenick, M. M., “NMDAR-independent, cAMP-dependent antidepressant actions of ketamine”, Molecular psychiatry, 24(12), 2019, 1833-1843.
[47]Stenovec, M., Lasič, E., Božić, M., Bobnar, S. T., Stout, R. F., Grubišić, V., ... & Zorec, R., “Ketamine inhibits ATP-evoked exocytotic release of brain-derived neurotrophic factor from vesicles in cultured rat astrocytes”, Molecular neurobiology, 53, 2015, 6882-6896.
[48]Li, N., Lee, B., Liu, R. J., Banasr, M., Dwyer, J. M., Iwata, M., ... & Duman, R. S., “mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists”, Science, 329(5994), 2010, 959-964.
[49]Holtmaat, A., & Svoboda, K., “Experience-dependent structural synaptic plasticity in the mammalian brain”, Nature Reviews Neuroscience, 10(9), 2009, 647-658.
[50]Kessels, H. W., & Malinow, R., “Synaptic AMPA receptor plasticity and behavior”, Neuron, 61(3), 2009, 340-350.
[51]Yoshihara, Y., De Roo, M., & Muller, D. (2009). “Dendritic spine formation and stabilization”, Current opinion in neurobiology, 19(2), 2009, 146-153.
[52]Newport, D. J., Carpenter, L. L., McDonald, W. M., Potash, J. B., Tohen, M., Nemeroff, C. B., & APA Council of Research Task Force on Novel Biomarkers and Treatments., “Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression”, American Journal of Psychiatry, 172(10), 2015, 950-966.
[53]Wray, N. H., Schappi, J. M., Singh, H., Senese, N. B., & Rasenick, M. M., “Molecular Psychiatry”, 24(12), 2019, 1833-1843.
[54]Lasič, E., Rituper, B., Jorgačevski, J., Kreft, M., Stenovec, M., & Zorec, R., “Subanesthetic doses of ketamine stabilize the fusion pore in a narrow flickering state in astrocytes”, Journal of Neurochemistry, 138(6), 2016, 909-917.
[55]Plant, A. L., “Supported hybrid bilayer membranes as rugged cell membrane mimics”, Langmuir, 15(15), 1999, 5128-5135.
[56]National Human Genome Research Institute: Cell Membrane (Plasma Membrane),2024 年 3 月 22 日,取自https://www.genome.gov/genetics-glossary/Cell-Membrane
[57]Siontorou, C. G., Nikoleli, G. P., Nikolelis, D. P., & Karapetis, S. K., “Artificial lipid membranes: Past, present, and future”, Membranes, 7(3), 2017, 38.
[58]Luchini, A., & Vitiello, G., “Mimicking the mammalian plasma membrane: An overview of lipid membrane models for biophysical studies”. Biomimetics, 6(1), 2020, 3.
[59]Casares, D., Escribá, P. V., & Rosselló, C. A., “Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues”, International journal of molecular sciences, 20(9), 2019, 2167.
[60]van Meer, G., & de Kroon, A. I., “Lipid map of the mammalian cell”, Journal of cell science, 124(1), 2011, 5-8.
[61]Microbe Notes: Phospholipid Bilayer- Structure, Types, Properties, Functions,2023 年 4 月 8 日,取自https://microbenotes.com/phospholipid-bilayer-structure-types-properties-functions/
[62]Helfrich, W., “Elastic properties of lipid bilayers: theory and possible experiments”, Zeitschrift für Naturforschung c, 28(11-12), 1973, 693-703.
[63]Graham, T. R., & Kozlov, M. M., “Interplay of proteins and lipids in generating membrane curvature”, Current opinion in cell biology, 22(4), 2010, 430-436.
[64]Bermudez, H., Hammer, D. A., & Discher, D. E., “Effect of bilayer thickness on membrane bending rigidity”, Langmuir, 20(3), 2004, 540-543.
[65]McMahon, H. T., & Boucrot, E., “Membrane curvature at a glance”, Journal of cell science, 128(6), 2015, 1065-1070.
[66]Cevc, G., & Marsh, D., “Phospholipid bilayers: physical principles and models”, Cell biology (USA), 1987, 5.
[67]Deuling, H. J., & Helfrich, W., “The curvature elasticity of fluid membranes: a catalogue of vesicle shapes”. Journal de Physique, 37(11), 1976 1335-1345.
[68]Seddon, J. M., & Templer, R. H., “Polymorphism of lipid-water systems”, Handbook of biological physics, 1, 1995, 97-160.
[69]Chernomordik, L. V., & Kozlov, M. M., “Protein-lipid interplay in fusion and fission of biological membranes”, Annual review of biochemistry, 72(1), 2003, 175-207.
[70]Helfrich, W., “Steric interaction of fluid membranes in multilayer systems”, Zeitschrift für Naturforschung A, 33(3), 1978, 305-315.
[71]Attard, G. S., Templer, R. H., Smith, W. S., Hunt, A. N., & Jackowski, S., “Modulation of CTP: phosphocholine cytidylyltransferase by membrane curvature elastic stress”, Proceedings of the National Academy of Sciences, 97(16), 2000, 9032-9036.
[72]Perozo, E., Kloda, A., Cortes, D. M., & Martinac, B., “Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating”, Nature structural biology, 9(9), 2002, 696-703.
[73]Zimmerberg, J., & Kozlov, M. M., “How proteins produce cellular membrane curvature”, Nature reviews Molecular cell biology, 7(1), 2006, 9-19.
[74]Shearman, G. C., Ces, O., Templer, R. H., & Seddon, J. M., “Inverse lyotropic phases of lipids and membrane curvature”, Journal of Physics: Condensed Matter, 18(28), 2006, S1105.
[75]Peeters, B. W., Piët, A. C., & Fornerod, M., “Generating membrane curvature at the nuclear pore: A lipid point of view”, Cells, 11(3), 2022, 469.
[76]Meher, G., Bhattacharjya, S., & Chakraborty, H., “Membrane cholesterol modulates oligomeric status and peptide-membrane interaction of severe acute respiratory syndrome coronavirus fusion peptide”, The Journal of Physical Chemistry B, 123(50), 2019, 10654-10662.
[77]Joardar, A., Pattnaik, G. P., & Chakraborty, H., “Mechanism of membrane fusion: Interplay of lipid and peptide”, The Journal of Membrane Biology, 255(2-3), 2022, 211-224.
[78]Jouhet, J., “Importance of the hexagonal lipid phase in biological membrane organization”, Frontiers in plant science, 4, 2013, 494.
[79]Kirk, G. L., Gruner, S. M., & Stein, D. L., “A thermodynamic model of the lamellar to inverse hexagonal phase transition of lipid membrane-water systems”, Biochemistry, 23(6), 1984, 1093-1102.
[80]Perutková, Š., Daniel, M., Dolinar, G., Rappolt, M., Kralj‐Iglič, V., & Iglič, A., “Stability of the inverted hexagonal phase”, Advances in planar lipid bilayers and liposomes, 9, 2009, 237-278.
[81]Rocha, S., Kumar, R., Horvath, I., & Wittung-Stafshede, P., “Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity”, Protein Engineering, Design and Selection, 32(2), 2019, 59-66.
[82]Andrade, S., Loureiro, J. A., & Pereira, M. C., “Caffeic acid for the prevention and treatment of Alzheimer′s disease: The effect of lipid membranes on the inhibition of aggregation and disruption of Aβ fibrils”, International Journal of Biological Macromolecules, 190, 2021, 853-861.
[83]Anton Paar: The principle of dynamic light scattering,取自https://wiki.anton-paar.com/en/the-principles-of-dynamic-light-scattering/
[84]Bhattacharjee, S., “DLS and zeta potential–what they are and what they are not?”, Journal of controlled release, 235, 2016, 337-351.
[85]WYATT TECHNOLOGY: Understanding Dynamic Light Scattering,取自https://www.wyatt.com/library/theory/dynamic-light-scattering-theory.html
[86]Gomes, A. J., Lunardi, C. N., Rocha, F. S., & Patience, G. S., “Experimental methods in chemical engineering: Fluorescence emission spectroscopy”, The Canadian Journal of Chemical Engineering, 97(8), 2015, 2168-2175.
[87]SCINCO:螢光光譜儀原理分析與應用,2023年5月22日,取自https://www.scincotaiwan.tw/zh-cht/TechnicalSupport_Detail-71.html
[88]Khanin, R., Parnas, H., & Segel, L., “Diffusion cannot govern the discharge of neurotransmitter in fast synapses”, Biophysical journal, 67(3), 1994, 966-972.
[89]Nicholls, D. G., Sihra, T. S., & Sanchez‐Prieto, J., “Calcium‐dependent and‐independent release of glutamate from synaptosomes monitored by continuous fluorometry”, Journal of neurochemistry, 49(1), 1987, 50-57.
[90]Boni, L. T., & Hui, S. W., “The mechanism of polyethylene glycol-induced fusion in model membranes”, Cell fusion , 1987, 301-330.
[91]Nasedkin, A., Davidsson, J., & Kumpugdee-Vollrath, M., “Determination of nanostructure of liposomes containing two model drugs by X-ray scattering from a synchrotron source’, Journal of Synchrotron Radiation, 20(5), 2013, 721-728.
[92]Li, T., Senesi, A. J., & Lee, B., “Small angle X-ray scattering for nanoparticle research”, Chemical reviews, 116(18), 2016, 11128-11180.
[93]Boldon, L., Laliberte, F., & Liu, L., “Review of the fundamental theories behind small angle X-ray scattering, molecular dynamics simulations, and relevant integrated application”, Nano reviews, 6(1), 2015, 25661.
[94]Seibt, S., & Ryan, T., “Microfluidics for time-resolved small-angle x-ray scattering”, Advances in Microfluidics and Nanofluids, 2020.
[95]Bjørnestad, V. A., & Lund, R., “Pathways of membrane solubilization: A structural study of model lipid vesicles exposed to classical detergents”, Langmuir, 39(11), 2023, 3914-3933.
[96]Skou, S., Gillilan, R. E., & Ando, N., “Synchrotron-based small-angle X-ray scattering of proteins in solution”, Nature protocols, 9(7), 2014, 1727-1739.
[97]Li, D., Fei, G., Xia, H., Spencer, P. E., & Coates, P. D., “Micro‐contact reconstruction of adjacent carbon nanotubes in polymer matrix through annealing‐Induced relaxation of interfacial residual stress and strain”, Journal of Applied Polymer Science, 2015, 132(33).
[98]Harper, P. E., Mannock, D. A., Lewis, R. N., McElhaney, R. N., & Gruner, S. M., “X-ray diffraction structures of some phosphatidylethanolamine lamellar and inverted hexagonal phases”, Biophysical Journal, 81(5), 2001, 2693-2706.
[99]Mozzi, R. L., & Warren, B. E., “The structure of vitreous silica”, Journal of Applied Crystallography, 2(4), 1969, 164-172.
[100]Kirk, G. L., & Gruner, S. M., “Lyotropic effects of alkanes and headgroup composition on the Lα-HII lipid liquid crystal phase transition: hydrocarbon packing versus intrinsic curvature”, Journal de Physique, 46(5), 1985, 761-769.
[101]Kollmitzer, B., Heftberger, P., Rappolt, M., & Pabst, G., “Monolayer spontaneous curvature of raft-forming membrane lipids”, Soft matter, 9(45), 2013, 10877-10884.
[102]Malinin, V. S., & Lentz, B. R., “On the analysis of elastic deformations in hexagonal phases”, Biophysical journal, 86(5), 2004, 3324-3328.
[103]Kulkarni, C. V., Wachter, W., Iglesias-Salto, G., Engelskirchen, S., & Ahualli, S., “Monoolein: a magic lipid?”, Physical Chemistry Chemical Physics, 13(8), 2011, 3004-3021.
[104]Marsh, D., “Pivotal surfaces in inverse hexagonal and cubic phases of phospholipids and glycolipids”, Chemistry and physics of lipids, 164(3), 2011, 177-183.
[105]張雯芳: <添加具有抗菌潛力的勝肽對磷脂質自組裝結構與彈性性質的影響>。碩士論文,國立中央大學,民國104年7月。
[106]Lin, C. M., Li, C. S., Sheng, Y. J., Wu, D. T., & Tsao, H. K., “Size-dependent properties of small unilamellar vesicles formed by model lipids”, Langmuir, 28(1), 2012, 689-700.
[107]Pabst, G., Rappolt, M., Amenitsch, H., & Laggner, P., “Structural information from multilamellar liposomes at full hydration: full q-range fitting with high quality x-ray data”, Physical Review E, 62(3), 2000, 4000.
[108]Leikin, S., Kozlov, M. M., Fuller, N. L., & Rand, R. P., “Measured effects of diacylglycerol on structural and elastic properties of phospholipid membranes”, Biophysical journal, 71(5), 1996, 2623-2632.
[109]Bridges, R. J., & Bradbury, N. A., “Cystic fibrosis, cystic fibrosis transmembrane conductance regulator and drugs: Insights from cellular trafficking”, Targeting trafficking in drug development, 2018, 385-425.
[110]Kozlovsky, Y., Efrat, A., Siegel, D. A., & Kozlov, M. M., “Stalk phase formation: effects of dehydration and saddle splay modulus”, Biophysical journal, 87(4), 2004, 2508-2521.
[111]Akimov, S. A., Molotkovsky, R. J., Kuzmin, P. I., Galimzyanov, T. R., & Batishchev, O. V., “Continuum models of membrane fusion: Evolution of the theory”, International journal of molecular sciences, 21(11), 2020, 3875.
指導教授 陳儀帆(Yi-Fan Chen) 審核日期 2024-9-18
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