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姓名 王佩文(Pei-Wen Wang)  查詢紙本館藏   畢業系所 系統生物與生物資訊研究所
論文名稱 從年齡動態網路探討疾病表現與疾病盛行率
(An Age dynamic network for human phenotypes and disease prevalence)
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摘要(中) 社會網絡已被應用在基因、蛋白質及代謝等各個領域來解釋其致病機轉。在這裡,我們利用醫院獲得醫療數據及由Online Mendelian Inheritance in Man ( OMIM)中取得基因與病徵等相關資料,藉由網路分析方法建立一個年齡動態疾病表現網絡(Age dynamic phenotypic disease network, ADPDN ),來分析不同年齡層下疾病網路的差異性。由結果顯示,當病人得到某個疾病時,伴隨得到第二種疾病的機率隨著年齡的增加而增加,而性別的不同也會造成差異。透過網路年齡的動態網路分析,證明疾病表現與疾病盛行率在基因層次上亦發現因為年齡及性別而有所不同,此方法結合醫療及基因資訊,建立疾病與基因的關聯性,期能對研究此相關領域者有所幫助。
摘要(英) Social networks have been investigated on genetic, proteomic, and metabolic fields as a viable path toward elucidating the origins of specific diseases. Here we use epidemiology view to summarizing correlations obtained from hospital dataset in an age dynamic phenotypic disease network (ADPDN). We show the evidence that the progression of disease connect by the links of the network is different for patients according to age and genders. Our study show that human phenotypes and disease prevalence can be demonstrated and by using network analysis, facilitating the potential to enhance our understanding of the origin and evolution of human diseases.
關鍵字(中) ★ 疾病網路
★ 疾病盛行率
★ 動態網路
★ 疾病組
★ 表現型
關鍵字(英) ★ dynamic network
★ disease network
★ disease prevalence
★ phenotype
★ diseaseome
論文目次 Chinese Abstract i
English Abstract ii
List of figures v
List of tables vi
Chapter 1 Introduction 1
1-1 Background 1
1-2 Motivation 3
Chapter 2 Material and methods 5
2-1 Material 5
2-1-1 OMIM Morbid Map 5
2-1-2 ICD-9-CM codes 5
2-2 Methods 6
2-2-1 Network analysis 6
2-2-1-1 Degree and degree distribution 6
2-2-1-2 Clustering coefficient 7
2-2-1-3 Scale-free network 7
2-2-2 Statistical analysis 8
2-2-2-1 Hypothesis 8
2-2-2-2 McNemar’s test 8
2-2-2-3 Odds ratio 10
2-3 Data preprocessing 11
Chapter 3 Result 14
3-1 Hospital dataset 14
3-2 Combined hospital dataset and OMIM disease-gene association 16
3-3 Statistical data 17
3-4 Degree distribution 21
3-5 The age dynamic phenotypic disease network 23
3-6 Case study 28
Chapter 4 Discussion 38
References 41
參考文獻 1. Dibbens, L.M., et al., X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet, 2008. 40(6): p. 776-81.
2. Scheffer, I.E., et al., Epilepsy and mental retardation limited to females: an under-recognized disorder. Brain, 2008. 131(Pt 4): p. 918-27.
3. Jamison, D.T., World Bank., and Disease Control Priorities Project., Disease control priorities in developing countries. 2nd ed. 2006, New York
Washington, DC: Oxford University Press ;
World Bank. xlii, 1401 p.
4. Kufe, D.W., et al., Cancer medicine 6. 6th ed. 2003, Hamilton, Ont. ; London: B.C. Decker.
5. Willett, W.C., Balancing life-style and genomics research for disease prevention. Science, 2002. 296(5568): p. 695-8.
6. Loscalzo, J., I. Kohane, and A.L. Barabasi, Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol, 2007. 3: p. 124.
7. McKusick, V.A., Mendelian inheritance in man : a catalog of human genes and genetic disorders. 12th ed. 1998, Baltimore: Johns Hopkins University Press.
8. Amberger, J., et al., McKusick's Online Mendelian Inheritance in Man (OMIM). Nucleic Acids Res, 2009. 37(Database issue): p. D793-6.
9. Ravasz, E., et al., Hierarchical organization of modularity in metabolic networks. Science, 2002. 297(5586): p. 1551-5.
10. Barabasi, A.L. and Z.N. Oltvai, Network biology: understanding the cell's functional organization. Nat Rev Genet, 2004. 5(2): p. 101-13.
11. Watts, D.J. and S.H. Strogatz, Collective dynamics of 'small-world' networks. Nature, 1998. 393(6684): p. 440-2.
12. Albert, R. and A.L. Barabasi, Statistical mechanics of complex networks. Reviews of Modern Physics, 2002. 74: p. 47-97.
13. Elston, R.C., J.M. Olson, and L. Palmer, Biostatistical genetics and genetic epidemiology. Wiley reference series in biostatistics. 2002, Chichester, England ;: New York, NY Wiley. xxiv, 831 p.
14. Fleiss, J.L., B.A. Levin, and M.C. Paik, Statistical methods for rates and proportions. 3rd ed. Wiley series in probability and statistics. 2003, Hoboken, N.J.: J. Wiley. xxvii, 760 p.
15. Kraemer, H.C., Reconsidering the odds ratio as a measure of 2x2 association in a population. Stat Med, 2004. 23(2): p. 257-70.
16. Knapp, R.G. and M.C. Miller, Clinical epidemiology and biostatistics. National medical series for independent study. 1992, Malvern, Pa ; Baltimore
London: Harwal Pub. Co ;
Williams & Wilkins. xi, 435 p.
17. Wassertheil-Smoller, S., Biostatistics and epidemiology : a primer for health and biomedical professionals. 3rd ed. 2004, New York: Springer-Verlag. xvi, 243 p.
18. Evans, H.S., et al., The risk of subsequent primary cancers after colorectal cancer in southeast England. Gut, 2002. 50(5): p. 647-52.
19. Tichansky, D.S., et al., Risk of second cancers in patients with colorectal carcinoids. Dis Colon Rectum, 2002. 45(1): p. 91-7.
20. Zubaidi, A., Multiple primary cancers of the colon, rectum, and the thyroid gland. Saudi J Gastroenterol, 2008. 14(4): p. 202-5.
21. Li, D., et al., Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet, 2006. 79(6): p. 1030-9.
22. Pasternak, J.J., An introduction to human molecular genetics : mechanisms of inherited diseases. 2nd ed. 2005, Hoboken, N.J.: Wiley-Liss. 631 p.
23. Slooter, A.J. and C.M. van Duijn, Genetic epidemiology of Alzheimer disease. Epidemiol Rev, 1997. 19(1): p. 107-19.
24. Jurkovicova, D., et al., Is the ApoE polymorphism associated with dilated cardiomyopathy? General Physiology and Biophysics, 2006. 25(1): p. 3-10.
25. Emre, M., et al., Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord, 2007. 22(12): p. 1689-707; quiz 1837.
26. Takahashi, R., [Animal models for familial Parkinson's disease]. Rinsho Shinkeigaku, 2007. 47(11): p. 938-40.
27. Levy, G., et al., Combined effect of age and severity on the risk of dementia in Parkinson's disease. Ann Neurol, 2002. 51(6): p. 722-9.
28. Yahr, M.D., D. Orosz, and D.P. Purohit, Co-occurrence of essential tremor and Parkinson's disease: clinical study of a large kindred with autopsy findings. Parkinsonism Relat Disord, 2003. 9(4): p. 225-31.
29. Sawle, G., Movement disorders in clinical practice. 1999, Oxford: Isis Medical Media. xi, 228 p.
30. Spanaki, C. and A. Plaitakis, Essential tremor in Parkinson's disease kindreds from a population of similar genetic background. Mov Disord, 2009.
31. Touraine, R.L., M. Zeniou, and A. Hanauer, A syndromic form of X-linked mental retardation: the Coffin-Lowry syndrome. Eur J Pediatr, 2002. 161(4): p. 179-87.
32. Raymond, F.L., X linked mental retardation: a clinical guide. Journal of Medical Genetics, 2006. 43(3): p. 193-200.
33. Hou, J.W., T.R. Wang, and S.M. Chuang, An epidemiological and aetiological study of children with intellectual disability in Taiwan. J Intellect Disabil Res, 1998. 42 ( Pt 2): p. 137-43.
34. Sandeep, T.C., et al., Second primary cancers in thyroid cancer patients: a multinational record linkage study. J Clin Endocrinol Metab, 2006. 91(5): p. 1819-25.
35. Guda, P., S.V. Chittur, and C. Guda, Comparative analysis of protein-protein interactions in cancer-associated genes. Genomics Proteomics Bioinformatics, 2009. 7(1-2): p. 25-36.
36. Haigis, K.M., et al., Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet, 2008. 40(5): p. 600-8.
指導教授 吳立青(Li-Ching Wu) 審核日期 2009-7-22
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