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| 題名: | Gene expression profiling of biological pathway alterations by radiation exposure |
| 作者: | 陳以錚;Wu, Lawrence Shih-Hsin;Liu, Ingrid Y.;Chen, Ching-Kai;Chi, Yu-Hsiang;Hsu, Paul Wei-Che;Weng, Julia Tzu-Ya;Lee, Kuei-Fang;Chen, Yi-Cheng |
| 貢獻者: | 管理學院資訊管理學系 |
| 關鍵詞: | Apoptosis;Bioinformatics;Cancer;Cancer therapies;Cobalt Radioisotopes;Computer science;Disease - genetics;DNA repair;Dose-Response Relationship, Radiation;Gene expression;Gene Expression Profiling;Gene Regulatory Networks;Genetic counseling;Health aspects;Humans;Immune system;Immunogenetics;Laboratories;Leukocytes, Mononuclear - metabolism;Leukocytes, Mononuclear - radiation effects;Metabolic disorders;Methods;Molecular biology;Nuclear energy;Signal Transduction - genetics;Studies |
| 日期: | 2014-01-01 |
| 上傳時間: | 2026-04-23 13:38:44 (UTC+8) |
| 出版者: | Hindawi Publishing Corporation;Cairo, Egypt: Hindawi Publishing Corporation |
| 摘要: | 摘要： Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted. Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiation, followed by array-based expression profiling. Gene set enrichment analysis indicated that the immune system and cancer development pathways appeared to be the major affected targets by radiation exposure. Therefore, 1 Gy radioactive exposure seemed to be a critical threshold dosage. In fact, after 1 Gy radiation exposure, expression levels of several genes including FADD, TNFRSF10B, TNFRSF8, TNFRSF10A, TNFSF10, TNFSF8, CASP1, and CASP4 that are associated with carcinogenesis and metabolic disorders showed significant alterations. Our results suggest that exposure to low-dose radiation may elicit changes in metabolic and immune pathways, potentially increasing the risk of immune dysfunctions and metabolic disorders.
其他題名： Biomed Res Int
出版者： Cairo, Egypt: Hindawi Publishing Corporation
出版日期： 2014-01-01
出處： BioMed research international, 2014-01, Vol.2014 (2014), p.1-9
資源來源： Publicly Available Content Database
版權： Copyright © 2014 Kuei-Fang Lee et al.
版權： COPYRIGHT 2014 John Wiley & Sons, Inc.
版權： Copyright © 2014 Kuei-Fang Lee et al. Kuei-Fang Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
版權： Copyright © 2014 Kuei-Fang Lee et al. 2014
識別號： ISSN: 2314-6133
識別號： ISSN: 2314-6141
識別號： EISSN: 2314-6141
識別號： DOI: 10.1155/2014/834087
識別號： PMID: 25276823 |
| 顯示於類別: | [資訊管理學系] 期刊論文
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