English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 80990/80990 (100%)
造訪人次 : 41636106      線上人數 : 1068
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋


    請使用永久網址來引用或連結此文件: http://ir.lib.ncu.edu.tw/handle/987654321/26580


    題名: The role of electroosmotic flow on in-vitro transdermal iontophoresis
    作者: Lin,RY;Ou,YC;Chen,WY
    貢獻者: 化學工程與材料工程學系
    關鍵詞: EXCISED HUMAN-SKIN;CONVECTIVE SOLVENT FLOW;TRANSPORT MECHANISMS;AMINO-ACIDS;MOUSE SKIN;WATER TRANSPORT;DELIVERY;MODEL;INVITRO;ENHANCEMENT
    日期: 1997
    上傳時間: 2010-06-29 17:31:35 (UTC+8)
    出版者: 中央大學
    摘要: Amino acids and their amino or carboxyl group blocked derivatives were selected to investigate the relative importance of the electroosmotic flow as comparing with the passive and electrical flows in transdermal iontophoresis. Specifically, the effects of the solute's hydrophobicity, the solute's charge, the buffer's salt concentration, and the electrical current density on the electroosmotic flow of transdermal were clearly demonstrated. In a summary, the electroosmotic flow direction enhanced the permeability of the positively charged solutes (anodic delivery), and the enhancements were diminished as the buffer's salt concentration increases; however, for anionic solutes and neutral solutes, the permeability reduced by increasing the buffer salt concentration was not as apparent as for cationic solutes since the negative effect of electroosmotic flow on anionic solutes was lessened as buffer concentration increases. Also, the increase in the electrical current density pushes up the permeability of cationic solutes by both increasing the electrical and electroosmotic flow; but for anionic solutes, the favor of the electrical flow in a higher electrical field was weakened by increasing negative electroosmotic flow. Furthermore, in the molecular weight range of the solutes under this investigation (89-300 g/mol), experimental results indicated that the hydrophobicity of solutes plays a more prominent role than molecular weight in passive diffusion, and the results allow to eliminate the argument of the permeability differences caused by the different molecular weights of the anionic solutes and the cationic solutes of this study.
    關聯: JOURNAL OF CONTROLLED RELEASE
    顯示於類別:[化學工程與材料工程研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML461檢視/開啟


    在NCUIR中所有的資料項目都受到原著作權保護.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 隱私權政策聲明