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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/50760


    Title: Schizosaccharomyces pombe Possesses Two Paralogous Valyl-tRNA Synthetase Genes of Mitochondrial Origin
    Authors: Chiu,WC;Chang,CP;Wen,WL;Wang,SW;Wang,CC
    Contributors: 生命科學系
    Keywords: METHIONYL-TRANSFER-RNA;SACCHAROMYCES-CEREVISIAE;BINDING DOMAIN;YEAST;TRANSLATION;AMINOACYLATION;RECOGNITION;REDUNDANCY;MECHANISM;COFACTOR
    Date: 2010
    Issue Date: 2012-03-27 18:09:40 (UTC+8)
    Publisher: 國立中央大學
    Abstract: Previous studies showed that VAS1 of Saccharomyces cerevisiae encodes both cytosolic and mitochondrial forms of valyl-tRNA synthetase (ValRS) through alternative initiation of translation. We show herein that except for Schizosaccharomyces pombe, all yeast species studied contained a single ValRS gene encoding both forms, and all of the mature protein forms deduced from those genes possessed an N-terminal appended domain (Ad) that was absent from their bacterial relatives. In contrast, S. pombe contained two distinct nuclear ValRS genes, one encoding the mitochondrial form and the other its cytosolic counterpart. Although the cytosolic form closely resembles other yeast ValRS sequences (similar to 60% identity), the mitochondrial form exhibits significant divergence from others (similar to 35% identity). Both genes are active and essential for the survival of the yeast. Most conspicuously, the mitochondrial form lacks the characteristic Ad. A phylogenetic analysis further suggested that both forms of S. pombe ValRS are of mitochondrial origin, and the mitochondrial form is ancestral to the cytoplasmic form.
    Relation: MOLECULAR BIOLOGY AND EVOLUTION
    Appears in Collections:[生命科學系] 期刊論文

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