English  |  正體中文  |  简体中文  |  Items with full text/Total items : 78728/78728 (100%)
Visitors : 34402009      Online Users : 743
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6013

    Title: 含奎寧酸─胞核甘單磷酸類似物之設計及合成;Design and Synthesis of Quinic Acid-Cytidine Monophosphate Aanlogous
    Authors: 吳心如;Hsin-ru Wu
    Contributors: 化學研究所
    Keywords: 奎寧酸;胞核甘單磷酸;唾液酸轉移酶;sialyltransferases;CMP-quinic acid
    Date: 2004-07-06
    Issue Date: 2009-09-22 10:11:53 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 經由唾液酸化而來的醣蛋白及醣脂質,存在於細胞表面,對於癌 細胞的轉移扮演著相當重要的角色。根據文獻報導醣類、核甘酸及醣 類衍生物的抑制性,針對以予體為基礎的抑制劑,發現核甘酸結構有 其存在的必要性,而唾液酸部分則不一定。基於這些已知的預測奎寧 酸─核甘單磷酸將對唾液酸轉移酶有其抑制效果,因此設計合成以 Fmoc-Asp(OBut)-OH 或Fmoc-Glu(OBut)-OH 為鏈鍵之奎寧酸─核甘 單磷酸類似物。 Sialylation of glycoproteins and glycolipids, which plays an important role in cell surface to cancer cell metastasis. The literatures reported that inhinitors including saccharid, nucleotide, and sugar derivatives displayed the importance and requirement of the cytidine nucleotide toward the inhibition of sialyltransferase, but the sialic acid moiety may not be essential. Base on these report evidence, the non-sialyl framework CMP-quinic acid derivatives will be effective inhibitors of sialyltransferases. Therefore, we utilize such as Fmoc-Asp(OBut)-OH or Fmoc-Glu(OBut)-OH to construct the synthesis of quinic acid-CMP analogues.
    Appears in Collections:[化學研究所] 博碩士論文

    Files in This Item:

    File SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 隱私權政策聲明