研究期間：10108~10207;Near-infrared (NIR) diffuse optical tomography (DOT) is a method for imaging biological tissue that has currently been developed since 1990s. For its sensing mechanism, it has been widely accepted that NIR tomography offers a way to noninvasively quantify and monitor changes in tissue hemoglobin concentration and oxygen saturation simultaneously, as well as several other chromophores, such as water, lipids, and cytochrome-c-oxidase. The ability to noninvasively quantify these chromophores is important for understanding physiological function and pathophysiological changes within tissues. For this three-year research project, thanks to related leading studies, including (1) two NIR DOT scanning devices using single rotating-source/detector mechanism have been designed and implemented. Compared with existing systems developed by other research groups, this scanning instrument can dramatically save source- and detection-fiber-bundles, and expect to offer comparable functionality. Additionally, the system achieves high angular spatial-resolution superior to other systems; although it needs longer NIR acquisition time. (2) A mammogram-based DOT module was implemented on a commercial mammographic system. Clinic trials for academic investigation justified its effectiveness. Based upon current promising results, in the proposed study for the next three years the following tasks are planed. Multi-wavelength functional DOT computation scheme－ to distinguish various tissue components in the tomographic images. Tissue optical-coefficient database using a double-sphere system－ to obtain true absorption- and scattering-coefficient images. Investigation on spatial resolution of DOT－ to evaluate the spatial resolution of DOT through experimentation. Design and implementation of prostrate-type diffuse optical tomographic system－ to build up a test bench for clinical trials. Justification of DOT through clinical trials－ to evaluate the sensitivity, specificity of DOT in breast tumor detection.
