English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 64745/64745 (100%)
造訪人次 : 20414416      線上人數 : 342
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋


    請使用永久網址來引用或連結此文件: http://ir.lib.ncu.edu.tw/handle/987654321/6543


    題名: 受體配體叢集在外力下的理論研究;Strength of ligand-receptor cluster under external force : deterministic model
    作者: 朱怡苹;Yi-Ping Chu
    貢獻者: 生物物理研究所
    關鍵詞: 鍵結強度;叢集;受體-配體;deterministic;strength;bond;ligand-receptor cluster
    日期: 2007-01-11
    上傳時間: 2009-09-22 10:21:33 (UTC+8)
    出版者: 國立中央大學圖書館
    摘要: 我們提出一個理論模型描述受到外力下的受體-配體叢集,並且修正了在貝爾(Bell) 模型中受體-配體的結合率。藉由研究受體-配體鍵結數目的速率方程式(rate equation),我們可以估計叢集的穩定度(生命期)。研究結果顯示當一具有N個平行受體-配體鍵結的叢集受到一外力F,叢集的生命期只和作用在一個受體-配體鍵結的力的大小f=F/N 有關。我們定義一臨界力fc:當f小於fc,叢集趨於穩定;當f大於fc,叢集的受體-配體鍵結會全部斷裂;當f等於fc,叢集的受體-配體鍵結會斷裂至一特定的鍵結數目(此時大部分的受體-配體是鍵結的),再經由鍵結受體-配體數的漲落使得叢集繼續斷裂。關於叢集的生命期,我們發現當f-> fc^+時,叢集的生命期小於貝爾模型的預測,並且正比於(f-fc)^(-1/2)。當(f-fc)/fc~O(1)時,叢集的生命期大於貝爾的預測,這主要是由於貝爾和我們的模型的初始受體-配體鍵結數目不同所造成。當f=fc 時,受體-配體鍵結數目的漲落變得重要,我們發現叢集的生命期正比於N^(1/3)。 We present a theoretical model that describes ligand-receptor cluster under external force. We modify the model of Bell [1] by considering the rebinding of broken bonds in a consistent way. The stability of the cluster is studied by the rate equation of Nb, the number of connected bonds. Our study reveals that for a cluster with N parallel bonds under external force F, the lifetime of the cluster depends only on the force acting on each bond f = F/N. There exists a critical force Fc = Nfc below which the cluster is stable and above which the cluster dissociates. When f = fc, the number of rupture events per unit time is equal to that of rebinding at Nb^* = Nnb^*. We find nb^*~1, i.e., the effect of rebinding is important when most of the bonds are connected. When f approaches fc from above, the cluster spends most of the time near nb^*, the true lifetime of the cluster is shorter than Bell’s prediction and has a power law behavior T ~(f − fc)^(−1/2). We also show that the true lifetime of the cluster is longer than Bell’s prediction when f is significantly greater than fc due to different number of connected bonds predicted by both theories in the absence of force. When f =fc, for a finite size cluster, the bond number fluctuation is important, the lifetime of the cluster is related to the cluster size by T ~N^(1/3).
    顯示於類別:[生物物理研究所 ] 博碩士論文

    文件中的檔案:

    檔案 大小格式瀏覽次數
    0KbUnknown830檢視/開啟


    在NCUIR中所有的資料項目都受到原著作權保護.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋  - 隱私權政策聲明