English  |  正體中文  |  简体中文  |  Items with full text/Total items : 74010/74010 (100%)
Visitors : 24685765      Online Users : 268
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6549

    Title: 粒子黏著於生物膜所引發的細胞攝入作用之物理研究;Physics of absorption induced endocytosis
    Authors: 蔡鳳卿;Feng-Ching Tsai
    Contributors: 生物物理研究所
    Keywords: 細胞攝入作用;endocytosis
    Date: 2007-07-03
    Issue Date: 2009-09-22 10:21:39 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 本論文提出研究由配體黏著於生物膜上所引發的細胞攝入作用 (ligand induced endocytosis)的理論。 我們考慮一分隔內外溶液的生物膜,且只有外溶液中含有可黏著於生物膜上之粒子,這些粒子黏著於生物膜上後,會聚集形成區塊 (domains);在生物膜上,夠大的區塊會形成囊泡而離開生物膜進入內溶液。我們的研究顯示,當系統達到穩定態 (steady state) 時 (1) 在合理的粒子吸收率 jon,解吸附率 joff,以及一個囊泡可以擁有的粒子數n*之下,區塊均是獨立成長的。(2) 當粒子的解吸附率夠大,而吸收率與一個囊泡可以擁有的粒子數夠小的時候,大部分的粒子在未加入區塊之前都離開生物膜數次。在這個情況下,每單位時間產生的囊泡數目與 (jon/joff)2 成正比。(3) 當粒子的吸收率夠大的時候,大部分的粒子在離開生物膜之前就已經加入區塊,且每單位時間產生的囊泡數目與粒子的吸收率成正比。 This thesis presents a theoretical analysis for ligand-induced endocytosis. We consider a flat membrane that separates the inner and outer fluids, the outer fluid contains particles that can be absorbed on the membrane and aggregate to form domains and the inner fluid does not, domains with sufficiently large size depart from the membrane and enter the inner fluid by vesicle fission. Assuming domain growth to be an irreversible diffusion-limited process, our study reveals that in the steady state: (i) At reasonable absorption rate jon, desorption rate joff and n*, number of particles in a vesicle, domains grow independently. (ii) When joff is sufficiently large, jon and n* are sufficiently small, particles leave the membrane many times before finally joining domains and number of vesicles produced per unit time scales as (jon/joff)2. (iii) When jon is sufficiently large, most particles absorbed on the membrane join domains before leaving the membrane and number of vesicles produced per unit time is proportional to number of particles absorbed on the membrane per unit time.
    Appears in Collections:[生物物理研究所 ] 博碩士論文

    Files in This Item:

    File SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 隱私權政策聲明