本次研究中，使用鋁和銅兩種造孔劑作為生物植入材料成功製備了鈦鋯基金屬玻璃多孔材。基於所需的孔隙率，鈦鋯基金屬玻璃粉末與間隔顆粒以不同的體積分率混合，然後通過熱壓機在壓力300MPa、溫度520℃和維持5分鐘的時間下處理混合粉末。在通過化學反應去除間隔顆粒後獲得多孔樣品。 XRD 和 TEM 分析表明多孔樣品在熱壓過程後仍保持非晶狀態。通過 SEM 檢查確認製造的多孔樣品的孔隙率參數與所選的間隔顆粒相似。通過使用 Al 和 Cu 間隔顆粒，產生的孔徑分別約為 195 μm和 120 μm，與人類骨骼 (100 μm -325 μm) 結構相似。根據人體骨骼結構設計孔隙度分佈（3 層和 5 層）。透過Gibson 和 Ashby 模型控制樣品的孔隙率，可以獲得與人體骨骼相似的機械性能。將樣品的孔隙率從 2% 增加到 72.4% 證實了壓縮強度（從 1261 MPa 到 24 MPa）和楊氏係數（從 79.7 GPa到 1.6 GPa）的降低。腐蝕測試結果證實，如製備的多孔樣品所示，通過孔隙率為 40.4%、Ecorr 為 0.25 V 和 Icorr 為 4.27 x 10-9 A/mm2的 Cu 間隔顆粒可以獲得高耐腐蝕性。在生物相容性測試中，使用 Cu 間隔顆粒製備的多孔樣品顯示細胞活力隨著孵育時間的增加而增加，這意味著細胞不斷生長。孵育 8 小時後，觀察到細胞遷移並顯示距離減少約 600 μm。鈣沉積率的結果始終高於 100%，表明該樣品在人體中具有優異的生物相容性。;In this study, porous samples of TiZr-based BMG foams were successfully fabricated by using Al and Cu space holders as bio-implant materials. The TiZr-based MG powder mixed with spacer particles in the various ratio of volume fractions based on the desired porosity. The mixed powder was then processed by a hot pressing machine under 300 MPa of pressure, 520°C temperature, and 5 minutes of holding time. The porous sample was obtained after removing the spacer particles with chemical reactions. The XRD and TEM analysis exhibit that the porous samples retain their amorphous state after hot pressing process. The porosity parameters of fabricated porous samples were confirmed similar to the selected spacer particles by SEM examination. By using Al and Cu spacer particles resulting pore size of approximately 195 and 120 μm, respectively, which is similar to the human bones (100-325 μm). The porosity distribution was designed in gradient porosity (3 and 5 layers) based on the gradient structure of the human bones. Similar mechanical properties to the human bones can be obtained by controlling the porosity of the samples based on the Gibson and Ashby model. Increasing porosity of the samples from 2% to 72.4% confirmed a decrease in the compressive strength (from 1261 to 24 MPa) and Young’s modulus (from 79.7 to 1.6 GPa). The corrosion test results show that high corrosion resistance can be obtained as shown in the fabricated porous sample by Cu spacer particles in porosity of 40.4% with Ecorr of 0.25 V and Icorr of 4.27 x 10-9 A/mm2. In the biocompatibility test, the fabricated porous sample by using Cu spacer particles show that cell viability increased with increasing incubation time which means that the cell was growing continuously. After 8 h incubation, the cell migration was observed and showing a distance reduction of approximately 600 μm. The results of calcium deposition rate are always higher than 100% show that the sample positively biocompatible in the human body.
