電刺激-響應藥物釋放水凝膠;Electrical stimulation-responsive drug release hydrogels

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Title:	電刺激-響應藥物釋放水凝膠;Electrical stimulation-responsive drug release hydrogels
Authors:	張翌暐;Chang, Yi-Wei
Contributors:	化學工程與材料工程學系
Keywords:	電刺激響應;藥物釋放;水凝膠;小角度X-ray散射
Date:	2022-07-27
Issue Date:	2022-10-04 10:58:37 (UTC+8)
Publisher:	國立中央大學
Abstract:	在本研究我們開發了一種電刺激響應水凝膠。我們利用合成將F127改質使其端基具苯磺酸官能基的三嵌段共聚物SF127。將F127與SF127依不同比例混合形成表面具苯磺酸官能基微胞，並透過裝載匹洛西卡(Piroxicam)藥物於微胞內成為藥物載體。再加入導電高分子PEDOT:PSS使其形成具複合導電水凝膠，並可應用貼片式電刺激藥物釋放材料。我們使用示差熱掃描分析DSC，複合導電水凝膠的臨界微包溫度 (TCMT) 和臨界溶膠-凝膠溫度 (TSGT)，也利用小角 X 光散射 (SAXS) 量測奈米載體封裝藥物前後微胞尺寸變化。此外，通過結合流變儀和小角 X 光散射SAXS (Rheo-SAXS) 即時原位量測，探討導電水凝膠在線性和非線性流變學中的黏彈性行為和微胞排列(體心立方(FCC)和六方堆積(HCP))方式的變化與電刺激藥物釋放之關係。;In this study we developed an electrical stimulation-responsive hydrogel. We synthesized the triblock copolymer (SF127), modified by poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), F127, so that its end groups had benzenesulfonic acid functional groups. F127 and SF127 were mixed in different ratios to form micelles with benzenesulfonic acid functional groups on the surface, and the micelles were loaded with Piroxicam to become a drug carrier. Subsequently, the conductive polymer PEDOT:PSS is added to form a composite conductive hydrogel, and a patch-type electrostimulation drug release material can be applied. Critical micelle temperature (TCMT) and critical sol-gel temperature (TSGT) of composite conducting hydrogels are measured by differential thermal scanning to analyze DSC, and the micelle size changes before and after drug encapsulation in nanocarriers are measured by small-angle X-ray scattering (SAXS). Furthermore, by combining a rheometer and small-angle X-ray scattering SAXS (Rheo-SAXS) instant in situ measurements, we investigate the relationship between the viscoelastic behavior of conductive hydrogels in linear and nonlinear rheology and the changes in the arrangement of micelles (body-centered cubic (FCC) and hexagonal packing (HCP)) with electrically stimulated drug release.
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] Electronic Thesis & Dissertation

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