| 摘要: | 316 不銹鋼是一種廣泛應用的醫療級不銹鋼，適用於手術設備、食品行業、沿海設施、廚具等領域。由於在 316 不銹鋼中添加了鉬，其耐腐蝕性和高溫強度得到了很大的提高。以往的研究已經通過表面修飾來擴大基材的應用範圍，比如將矽片上應用矽烷、金表面上應用磷酸等。具有不同頭基和不同烷基鏈長的分子已被廣泛應用於許多不同的金屬表面。在本研究中，我們合成了三種具有不同烷基鏈的羧酸丙烯醯胺分子，分別是丙烯醯胺基乙酸 (2-AE)、6-丙烯醯胺基己酸 (6-AH) 和 11-丙烯醯胺基十一酸 (11-AU)。在單體的修飾過程中，存在兩個區域：(1) 極性丙烯醯胺 (2) 疏水烷基鏈。這兩個區域之間的相互作用將決定整體結構和有序性。通過氫鍵作用，內部二級醯胺被用來控制分子定向和提高單層穩定性。此外，丙烯酸酯結構可以通過聚合技術構建具有可調性性質的各種分子結構。2-甲基丙烯酰氧乙基磷酸膽鹼 (MPC) 具有抗菌和抗污染的作用。然而，它缺乏機械穩定性。為了提高穩定性，一種好的方法是將我們合成的三種單體進行聚合。核磁共振光譜 (1H NMR) 可用於表徵三種不同單體的化學結構。此外，我們可以通過循環伏安法 (CV) 和傅立葉轉換紅外光譜 (FT-IR) 了解不同烷基鏈的羧酸丙烯醯胺分子在 316 不銹鋼上的結合親和力。在與 MPC 進行聚合並修飾在 316 不銹鋼上之後，我們可以通過使用 FT-IR、1H NMR、X 射線光電子能譜 (XPS) 和小角度 X 射線散射(SAXS) 來檢測功能基團和分子狀態。最後，我們將修飾後的 316 不銹鋼基材進行細菌和蛋白質貼附測試，確定以哪種高分子修飾會得到最佳效果。;The 316 stainless steel is a widely used medical-grade stainless steel. It suits surgical equipment, the food industry, coastal facilities, kitchenware, etc. Due to the addition of molybdenum to 316 stainless steel, its corrosion resistance and high-temperature strength have been greatly improved. Previous studies have been conducted to expand the application range of substrates by surface modification, such as silane applied to silicon wafers, phosphonic acid applied to gold surfaces, etc. Molecules with different head groups and different alkyl chain lengths have been widely used in many different metal surfaces. In this study, we have synthesized three carboxyl acrylamide with different alkyl chains, acryloylglycine (2-AE), 6-acrylamidohexanoic acid (6-AH), and 11-acrylamidoundecanoic acid (11-AU). For the deposition of monomers, there are two regions：(1) the polar amide and (2) the hydrophobic alkyl chain. The interactions of these two regions will dictate the overall assembly structure and order. Internal secondary amides have been incorporated with the goals of controlling the molecular orientation and improving monolayer stability by hydrogen bonding interactions. Besides, an acrylate structure can build various molecular architectures with tunable properties via the polymerization technique. 2- Methacryloyloxyethyl phosphorylcholine (MPC) has the effect of antibacterial and antifouling. However, it lacks mechanical stability. To improve the stability, a good method is to do the polymerization with the three monomers we synthesized. Nuclear magnetic resonance spectroscopy (1H NMR) characterizes the chemical structure of three different monomers. Furthermore, we can know the binding affinity of carboxylic acid on the 316 stainless steel through cyclic voltammetry (CV) and FT-IR (SR80). After polymerization with MPC and coating on the 316 stainless steel, the functional groups and chemical states can be examined using various techniques such as FT-IR, 1H NMR, X-ray photoelectron spectroscopy (XPS), and Small Angle X-ray Scattering (SAXS). Subsequently, the modified 316 stainless steel substrates can be subjected to bacteria and protein adsorption tests to evaluate the effectiveness of different random copolymers and determine the one with the most favorable outcome. |
