Lubricant and Anti-fouling Coatings for Silicone Catheter

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Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/94651

Title:	Lubricant and Anti-fouling Coatings for Silicone Catheter
Authors:	范曉梅;Mai, Pham Thi
Contributors:	化學工程與材料工程學系
Keywords:	矽膠;醫療塗層;烴基插入交聯反應 (CHic);聚乙烯吡咯烷酮 (PVP);2-基丙烯醯氧基乙基磷醯膽鹼 (MPC);3-甲基丙烯醯氧基-2-羥丙基-4-氧基二苯甲酮 (MHPBP);Silicone;Medical coatings;C-H insertion crosslinking reaction (CHic);Polyvinylpyrrolidone (PVP);2-methacryloyloxy phosphorylcholine (MPC);3-methacryloyloxy-2-hydroxypropyl-4-oxybenzophenone (MHPBP)
Date:	2024-07-18
Issue Date:	2024-10-09 15:21:35 (UTC+8)
Publisher:	國立中央大學
Abstract:	矽膠具有優異的機械性質、低毒性和低生產成本，因此廣泛應用在醫療領域。然而，矽膠的疏水性在人體植入過程中會引發生物污損問題，限制其應用性。為了解決此困境，本研究採用簡單而有效的兩步塗層工藝來提升矽膠導管的表面性能。第一層作為基底層，將矽膠導管浸泡在由四種單體合成之共聚物溶液中，各具特定功能： 2-甲基丙烯醯氧基乙基三甲基氯化銨 (TMAEMA) 為季銨鹽，具有抗菌性能；甲基丙烯酸十二烷基酯 (DMA) 可促進與矽膠表面間的疏水作用力；3-甲基丙烯醯氧基-2-羥丙基-4-氧基二苯甲酮 (MHPBP) 含有苯甲酮基團，能在紫外線照射下通過烴基插入交聯反應 (CHic) 與矽膠表面進行交聯；乙烯基吡咯烷酮 (NVP) 作為除氧劑，可提高交聯效率。隨後，在基底層上以兩種不同的溶液作為功能性塗層，分別是聚乙烯吡咯烷酮(PVP) 及含有2-甲基丙烯醯氧基乙基磷醯膽鹼和甲基丙烯酸十二烷基酯的共聚物 (MPC-DMA)，這些溶液用於誘導矽膠表面使其具有親水性和抗污性。本研究詳述合成共聚物的方法，並使用水接觸角儀、摩擦力測試、FTIR和AFM對塗層表面進行鑑定及分析，這些分析證實雙層塗層在矽膠表面的成功塗佈。此外，還進行細菌黏附測試、蛋白質吸附測試、溶血測試和細胞毒性測試，以評估塗層矽膠表面的抗污和生物相容性。結果顯示，PVP和MPC-DMA在上述實驗中具有卓越的性能，適合作為仿生的矽膠基材醫用塗層。 ;Silicone is a widely used material in medical applications due to its excellent mechanical properties, low toxicity, and low production cost. However, the hydrophobicity of silicone limits its medical implementation due to biofouling concerns which can cause challenges during prolonged human implantation. In this study, a simple and effective two-step coating process was employed to enhance the surface properties of silicone catheters. In the first step for the primer layer, silicone catheters were immersed in a solution containing a copolymer. This copolymer, synthesized from four monomers, serves distinct functions: 2-methacryloyloxy ethyl trimethylammonium chloride (TMAEMA) acts as a quaternary ammonium, known for its antibacterial properties; dodecyl methacrylate (DMA) facilitates hydrophobic-hydrophobic interactions with the silicone surface; 3-methacryloyloxy-2-hydroxypropyl-4-oxybenzophenone (MHPBP) contains a benzophenone group that can induce crosslinking with silicone surface under UV irradiation condition via C-H insertion crosslinking reactions (CHic); and n-vinyl-2-pyrrolidone (NVP) acts as oxygen scavenger to make the crosslinking efficiency. Subsequently, in the second step for functional layer, the two distinct solutions were utilized: one comprising polyvinylpyrrolidone (PVP) and the other containing a copolymer (2-methacryloyloxy phosphorylcholine-co-dodecyl methacrylate) (MPC-DMA). These solutions were employed to induce hydrophilic and antifouling properties on the silicone surface. The methods to synthesize copolymers were also described. Furthermore, the coated surfaces were characterized using water contact angle measurements (WCA), friction test, Fourier-transform infrared spectroscopy (FTIR), and atomic force microscope (AFM). These characterization techniques confirmed the successful deposition of dual layers onto the silicone surface and allowed assessment of their surface properties. Additionally, bacterial adhesion test, protein adsorption test, hemolysis test, cytotoxicity test, and encrustation test were conducted to evaluate the anti-fouling and biocompatibility abilities of the coated silicone surface. Following all the tests, both PVP and MPC-DMA exhibited good lubricity, excellent antifouling, and biocompatibility properties, rendering them suitable as medical coatings on silicone substrates.
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] Electronic Thesis & Dissertation

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