| 摘要: | 相較於傳統批次反應器，流動式反應器具備一些明顯的優勢，包括均勻混合、熱量與質量傳送效率高、易於控制停留時間、高再現性等。因此，流動反應器系統可通過選擇合適之反應參數，快速確定其最佳反應條件，並應用於大規模生產以增加生產效率。
因此在本研究中，我們使用聚全氟乙烯丙烯 (Fluorinated Ethylene Propylene) 透明管作為連續反應器，以綠色LED光作為光聚合的光源。此外，我們還利用泵控制器自動調整各種反應參數，如停留時間、單體濃度和光催化劑/單體比例，以及使用自動樣品收集器對產物進行分類。此外，由於其簡單的設計和低成本，這種管狀連續反應器適用於擴大生產和降低合成成本。它還可以用於高通量合成，以快速篩選共聚物組成，從而實現對各種聚合物的快速合成和分析。在本實驗中，丙烯醯胺表現出更好的反應活性和轉化率。因此，我們以磺基甜菜鹼丙烯醯胺（Sulfobetaine Acrylamide） 和丙烯醯甘氨（Acryloylglycine） 為基礎，合成了約為25,000 g/mol的共聚物。磺基甜菜鹼丙烯醯胺提供抗菌和抗污垢的效果。而丙烯酰甘氨則可以通過氫鍵修飾於316不鏽鋼基板上。通過核磁共振氫譜 （Nuclear Magnetic Resonance Spectroscopy） 譜學鑑定共聚物的結構和轉化率，然後使用凝膠滲透層析 （Gel Permeation Chromatography） 確認不同條件下的分子量。最後，我們通過將共聚物接枝到不銹鋼基板上進行表面修飾，並使用水接觸角測量儀確認其親水性。使用X射線光電子能譜儀 （X-ray photoelectron spectroscopy） 和衰減全反射傅立葉變換紅外光譜儀 （Attenuated Total Reflection-Fourier Transform Infrared Spectrometer） 驗證塗層的表面組成。進行細菌和蛋白質附著測試以評估塗層的抗污垢性能。
;Compared to traditional batch reactors, flow reactors offer several notable advantages, including uniform mixing, high efficiency of heat and mass transfer, ease of controlling residence time, and high reproducibility. Therefore, flow reactor systems can rapidly determine optimal reaction conditions through appropriate selection of reaction parameters and can be applied to large-scale production to increase production efficiency.
In this study, a fluorinated ethylene propylene (FEP) transparent tubing was utilized as a continuous reactor, with green LED light serving as the light source for photopolymerization. Additionally, we utilized a pump controller to automatically adjust various reaction parameters, such as residence time, monomer concentration, and photocatalyst/monomer ratio, and an automatic sample collector to sort products. Furthermore, this tubular continuous reactor, due to its simple design and low cost, is suitable for scaling up production and reducing synthesis costs. It can also be used for high-throughput synthesis to screen copolymer compositions rapidly, thereby enabling the rapid synthesis and analysis of a wide range of polymers. In this experiment, acrylamide showed better reactivity and conversion. Therefore, we synthesized a copolymer with a molecular weight of approximately 25,000 g/mole based on sulfobetaine acrylamide (SBAA) and acryloylglycine (AG). Sulfobetaine acrylamide has the effect of antibacterial and antifouling. Acryloylglycine can be modified on the 316 stainless steel substrates through hydrogen bonding. The copolymers were identified using proton nuclear magnetic resonance (1H NMR) spectroscopy to determine their structures and conversion rates, followed by gel permeation chromatography (GPC) to confirm molecular weights under different conditions. Finally, we modified stainless steel substrates by grafting the copolymers, and their hydrophilicity was confirmed using a water contact angle measurement instrument. The surface composition of the coatings was verified using X-ray photoelectron spectroscopy (XPS) and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR). Bacterial and protein attachment tests were conducted to assess the anti-fouling properties of the coatings. |
