結合漫反射光譜及蒙地卡羅分析建立瘀傷時間模型

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題名:	結合漫反射光譜及蒙地卡羅分析建立瘀傷時間模型
作者:	王翊蓁;Wang, Yi-Zhen
貢獻者:	光電科學與工程學系
關鍵詞:	漫反射光譜;瘀傷;蒙地卡羅;主成分分析法;Diffuse reflectance spectroscopy;Bruise skin;Monte Carlo;Principal components analysis
日期:	2024-08-21
上傳時間:	2024-10-09 15:45:18 (UTC+8)
出版者:	國立中央大學
摘要:	光學檢測技術因為具有不破壞生物體本身的優點，普遍被應用在生醫研究上，近年來隨著健康意識逐漸抬頭，非侵入式技術漸漸應用於人體的生理指數分析上。　漫反射光譜(DRS, diffuse reflectance spectroscopy)是光學檢測技術在人體上最常被使用的技術，藉由光譜表現、反射率與濃度的分析可獲得多項無法用肉眼觀察到的皮下組織數據，例如帶氧血紅素、不帶氧血紅素、膽紅素等等數值，這些數據有助於了解受試者當下的瘀傷程度，以及瘀傷的癒合及形成時間。　本研究以漫反射光譜量測系統搭配主成分分析法，透過類神經網路獲得皮下組織含量變化，進而進行生理數值分析。透過收集有瘀傷的受試者，將受傷區域採集漫反射光譜及二維影像，透過主成分分析法找出漫反射光譜中三大主要成分，再以擬合方式取得投影量對應帶氧血紅素、不帶氧血紅素與膽紅素濃度三者的關係，使用台大宋孔彬老師實驗室提供的類神經系統擬合出的濃度資訊可應用於受試者的生理數值分析上，建立瘀傷形成及癒合的時間模型，而後擴大受試者的基底可以將時間模型更完善，並應用在生醫研究上。;Optical detection technology is widely used in biomedical research because it has the advantage of not damaging the organism itself. In recent years, with the gradual rise of health awareness, non-invasive technology has gradually been applied to the analysis of physiological indexes of the human body. Diffuse reflectance spectroscopy (DRS) is the most commonly used optical detection technology on the human body. Through the analysis of spectral performance, reflectance and concentration, a number of subcutaneous tissue data that cannot be observed with the naked eye can be obtained, such as Oxygenated Hemoglobin, Deoxygenated Hemoglobin, bilirubin, biliverdin etc. These data help to understand the subject′s current degree of bruises, as well as the healing and formation time of the bruises. This study uses a diffuse reflectance spectroscopy measurement system coupled with principal component analysis to obtain changes in subcutaneous tissue content through a neural network, and then conducts physiological numerical analysis. By collecting subjects with bruises, the diffuse reflectance spectrum and two-dimensional images of the injured area were collected, and the four main components in the diffuse reflectance spectrum were found through principal component analysis, and then the projection volume corresponding bands were obtained by fitting. The relationship between oxygenated hemoglobin, non-oxygenated hemoglobin and bilirubin concentration. The concentration information fitted using the neural system provided by Professor Song Kong Bin′s laboratory at National Taiwan University can be applied to the analysis of the physiological values of the subjects to establish blood stasis. Time model of injury formation and healing, and then expanding the basis of subjects can improve the time model and apply it to biomedical research.
顯示於類別:	[光電科學研究所] 博碩士論文

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