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| 題名: | Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments |
| 作者: | 樋口亞紺;Kao, Ta-Chun;Lee, Henry Hsin-chung;Higuchi, Akon;Ling, Qing-Dong;Yu, Wan-Chun;Chou, Yu-Hsuan;Wang, Pin-Yu;Suresh Kumar, S.;Chang, Yu;Hung Chen, Yung;Chang, Yung;Chen, Da-Chung;Hsu, Shih-Tien |
| 貢獻者: | 工學院化學工程與材料工程學系 |
| 關鍵詞: | Adipocytes - physiology;Aged;Aged, 80 and over;Animals;Biocompatible Materials;Biological and medical sciences;Biomaterials;Biomedical materials;Bulging;Cancer;Cell Differentiation;Cell Line, Tumor;cell-sorting dish;Cells, Cultured;Colon;Colonic Neoplasms - pathology;Culture;extracellular matrix;Gene Expression Regulation, Neoplastic - genetics;Gene Expression Regulation, Neoplastic - physiology;Humans;Immunohistochemistry;Materials research;Materials science;Medical sciences;Mice;Middle Aged;nanosegment;Nanostructure;Neoplasm Transplantation;Neoplastic Stem Cells - physiology;Pluronic;Poloxamer;Polystyrenes;stem cell;Stem cells;Stem Cells - physiology;Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases;Surgical implants;Technology. Biomaterials. Equipments |
| 日期: | 2014-04-01 |
| 上傳時間: | 2026-04-21 14:24:55 (UTC+8) |
| 出版者: | John Wiley and Sons Inc.;Hoboken, NJ: Blackwell Publishing Ltd |
| 摘要: | 摘要： AbstractCancer‐initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)‐grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix‐coated dishes. CSCs persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumorigenic clones. The purification or depletion (suppression) of CSCs should be useful for analyzing CSC characteristics and for clinical application. CSCs can be selectively suppressed from colon cancer cells containing adipose‐derived stem cells (ADSCs) on Pluronic‐grafted dishes, while ADSCs remain on the dishes. ADSCs on Pluronic‐grafted dishes after the suppression of the CSCs can differentiate into osteoblasts, chondrocytes, adipocytes, cardiomyocytes, and neuronal cells. The CSCs and ADSCs exhibited different characteristics. The selection of ADSCs was possible on Pluronic‐grafted dishes that suppressed the CSCs from the fat tissues of cancer patients (i.e., cell‐sorting dishes), which was explained by specific biomedical characteristics of Pluronic. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 463–476, 2014.
其他題名： J. Biomed. Mater. Res
出版者： Hoboken, NJ: Blackwell Publishing Ltd
出版日期： 2014-04-01
出處： Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014-04, Vol.102 (3), p.463-476
資源來源： Alma/SFX Local Collection
版權： 2015 INIST-CNRS
版權： Copyright © 2013 Wiley Periodicals, Inc.
識別號： ISSN: 1552-4973
識別號： ISSN: 1552-4981
識別號： EISSN: 1552-4981
識別號： DOI: 10.1002/jbm.b.33024
識別號： PMID: 24039170 |
| 顯示於類別: | [化學工程與材料工程學系 ] 期刊論文
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