資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.lib.ncu.edu.tw/handle/987654321/101375
|
| 題名: | Generation of pluripotent stem cells without the use of genetic material |
| 作者: | 樋口亞紺;Higuchi, Akon;Ling, Qing-Dong;Kumar, S Suresh;Munusamy, Murugan A;Alarfaj, Abdullah A;Chang, Yung;Kao, Shih-Hsuan;Lin, Ke-Chen;Wang, Han-Chow;Umezawa, Akihiro |
| 貢獻者: | 工學院化學工程與材料工程學系 |
| 關鍵詞: | 13/100;42/109;631/61/2320;Animals;Genetic Techniques;Humans;Laboratory Medicine;Medicine;Medicine & Public Health;Mice;mini-review;Pathology;Pluripotent Stem Cells - cytology |
| 日期: | 2015-01-01 |
| 上傳時間: | 2026-04-21 14:32:03 (UTC+8) |
| 出版者: | Nature Publishing Group;New York: Elsevier Inc |
| 摘要: | 摘要： Induced pluripotent stem cells (iPSCs) provide a platform to obtain patient-specific cells for use as a cell source in regenerative medicine. Although iPSCs do not have the ethical concerns of embryonic stem cells, iPSCs have not been widely used in clinical applications, as they are generated by gene transduction. Recently, iPSCs have been generated without the use of genetic material. For example, protein-induced PSCs and chemically induced PSCs have been generated by the use of small and large (protein) molecules. Several epigenetic characteristics are important for cell differentiation; therefore, several small-molecule inhibitors of epigenetic-modifying enzymes, such as DNA methyltransferases, histone deacetylases, histone methyltransferases, and histone demethylases, are potential candidates for the reprogramming of somatic cells into iPSCs. In this review, we discuss what types of small chemical or large (protein) molecules could be used to replace the viral transduction of genes and/or genetic reprogramming to obtain human iPSCs.
其他題名： Lab Invest
出版者： New York: Elsevier Inc
出版日期： 2015-01-01
出處： Laboratory Investigation, 2015-01, Vol.95 (1), p.26-42
資源來源： Alma/SFX Local Collection
版權： 2014 United States & Canadian Academy of Pathology
版權： United States & Canadian Academy of Pathology 2014
版權： Copyright Nature Publishing Group Jan 2015
識別號： ISSN: 0023-6837
識別號： ISSN: 1530-0307
識別號： EISSN: 1530-0307
識別號： DOI: 10.1038/labinvest.2014.132
識別號： PMID: 25365202 |
| 顯示於類別: | [化學工程與材料工程學系 ] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 21 | 檢視/開啟 |
|
在NCUIR中所有的資料項目都受到原著作權保護.
|
