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| 題名: | Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents |
| 作者: | 謝發坤;Wang, Shao-Chun;Hsu, Yu-Shen;Hsiao, Chia-Teng;Wu, Chang-Cheng;Sue, Yu-Chein;Alshehri, Saad M.;Ahamad, Tansir;Yamauchi, Yusuke;Chen, Jeffrey E.;Wu, Kevin C.-W.;Shieh, Fa-Kuen |
| 貢獻者: | 理學院化學學系 |
| 關鍵詞: | Aqueous-Solution;Chemistry;Chemistry and Materials Science;Complexes;Design;Drug-Delivery;Exchange;Heavy-Metal Ions;High-Relaxivity;Inorganic Chemistry;Lanthanoid(Iii) Ions;Nanoparticles;Organic Chemistry;Polymer Sciences;Spectroscopy |
| 日期: | 2016-01-01 |
| 上傳時間: | 2026-04-21 14:40:34 (UTC+8) |
| 出版者: | Springer New York;New York: Springer Science and Business Media LLC |
| 摘要: | 摘要： We report a series of SBA-15 type mesoporous silica (MS) possessing functional annulated rings of different sizes obtained by post-synthesis grafting with diamines containing backbones and different numbers of carbon atoms as efficient magnetic resonance imaging (MRI) contrasting agents. Interestingly, lanthanide ion adsorption assays in aqueous solutions of pH 7 at room temperature showed that adsorption efficiency was higher for materials with rings than those without rings. Furthermore, annulated MS synthesized with 1,5-diaminopetane exhibited selective chelation with smaller Yb(III) ions owing to the “macrocyclic effect” of the cation cavity that offers a “best fit.” Additionally, Gd(III) ions chelated with the material modified by 1, 5-diaminopetane denoted as Gdannulated-MS exhibited high r2/r1 relaxivities of 12, 12, and 28 while measured with 7.0 T (300 MHz), 9.4 T (400 MHz), and 11.4 T (500 MHz), respectively. Finally, the nanoscale parent materials for annulated modification were successfully synthesized for further in vivo applications. The MS materials thus obtained open auxiliary avenues for selective lanthanide ion absorption via manipulation of the annular ring size to be potentially applied in new generation MRI contrast agents.
其他題名： J Inorg Organomet Polym
出版者： New York: Springer Science and Business Media LLC
出版日期： 2016-01-01
出處： Journal of Inorganic and Organometallic Polymers and Materials, 2016-01, Vol.26 (1), p.165-171
版權： Springer Science+Business Media New York 2015
識別號： ISSN: 1574-1443
識別號： EISSN: 1574-1451
識別號： DOI: 10.1007/s10904-015-0280-8 |
| 顯示於類別: | [化學學系] 期刊論文
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