摘要： The enantioselective synthesis of natural brevipolide H is reported for the first time. By way of Sharpless epoxidation of penta-1,4-dien-3-ol, both enantiomerically pure epoxides were converted to the corresponding olefins for cross metathesis. Subsequent transformations, including epoxide ring opening, esterifications, cyclopropanation, oxidation and ring-closing metathesis, provided the target molecule. This synthesis successfully addresses previous shortcomings in preparing brevipolides. The enantioselective synthesis of natural brevipolide H is reported for the first time. 其他題名： Org Biomol Chem 出版者： England 出版日期： 2016-07-12 出處： Organic & biomolecular chemistry, 2016-07, Vol.14 (28), p.6762-6768 資源來源： Royal Society of Chemistry 識別號： ISSN: 1477-0520 識別號： ISSN: 1477-0539 識別號： EISSN: 1477-0539 識別號： DOI: 10.1039/c6ob01071g 識別號： PMID: 27337141
