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| 題名: | BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior |
| 作者: | 范世榮;Corrigan, Laura;Redhai, Siamak;Leiblich, Aaron;Fan, Shih-Jung;Perera, Sumeth M.W.;Patel, Rachel;Gandy, Carina;Wainwright, S. Mark;Morris, John F.;Hamdy, Freddie;Goberdhan, Deborah C.I.;Wilson, Clive |
| 貢獻者: | 生醫理工學院生命科學系 |
| 關鍵詞: | Animal behavior;Animals;Bone Morphogenetic Proteins - physiology;Cellular biology;Drosophila melanogaster;Drosophila Proteins - physiology;Epithelial Cells - metabolism;Exosomes - physiology;Female;Females;Genitalia, Female - cytology;Genitalia, Male - metabolism;Insects;Lysosomes - metabolism;Male;Membrane Fusion;Membrane Microdomains - metabolism;Multivesicular Bodies - metabolism;Peptides;Protein Transport;Proteins;Reproduction;Reproductive system;Secretory Vesicles - metabolism;Sexual Behavior, Animal;Signal Transduction;Spermatozoa - metabolism;Tetraspanin 30 - metabolism;Vacuoles - metabolism |
| 日期: | 2014-01-01 |
| 上傳時間: | 2026-04-23 11:11:51 (UTC+8) |
| 出版者: | Rockefeller University Press;United States: Rockefeller University Press |
| 摘要: | 摘要： Male reproductive glands secrete signals into seminal fluid to facilitate reproductive success. In Drosophila melanogaster, these signals are generated by a variety of seminal peptides, many produced by the accessory glands (AGs). One epithelial cell type in the adult male AGs, the secondary cell (SC), grows selectively in response to bone morphogenetic protein (BMP) signaling. This signaling is involved in blocking the rapid remating of mated females, which contributes to the reproductive advantage of the first male to mate. In this paper, we show that SCs secrete exosomes, membrane-bound vesicles generated inside late endosomal multivesicular bodies (MVBs). After mating, exosomes fuse with sperm (as also seen in vitro for human prostate-derived exosomes and sperm) and interact with female reproductive tract epithelia. Exosome release was required to inhibit female remating behavior, suggesting that exosomes are downstream effectors of BMP signaling. Indeed, when BMP signaling was reduced in SCs, vesicles were still formed in MVBs but not secreted as exosomes. These results demonstrate a new function for the MVB–exosome pathway in the reproductive tract that appears to be conserved across evolution.
其他題名： J Cell Biol
出版者： United States: Rockefeller University Press
出版日期： 2014-09-01
出處： Journal of Cell Biology, 2014-09, Vol.206 (5), p.671-688
資源來源： Alma/SFX Local Collection
版權： 2014 Corrigan et al.
版權： Copyright Rockefeller University Press Sep 1, 2014
版權： 2014 Corrigan et al. 2014
識別號： ISSN: 0021-9525
識別號： ISSN: 1540-8140
識別號： EISSN: 1540-8140
識別號： DOI: 10.1083/jcb.201401072
識別號： PMID: 25154396
識別號： CODEN: JCLBA3 |
| 顯示於類別: | [生命科學系] 期刊論文
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