摘要： Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a major nosocomial pathogen that is widespread in both health-care facilities and in the community at large, as a result of direct host-to-host transmission. Several virulence factors are associated with pathogen transmission to naive hosts. Immunodominant surface antigen B (IsaB) is a virulence factor that helps Staphylococcus aureus to evade the host defense system. However, the mechanism of IsaB on host transmissibility remains unclear. We found that IsaB expression was elevated in transmissible MRSA. Wild-type isaB strains inhibited autophagic flux to promote bacterial survival and elicit inflammation in THP-1 cells and mouse skin. MRSA isolates with increased IsaB expression showed decreased autophagic flux, and the MRSA isolate with the lowest IsaB expression showed increased autophagic flux. In addition, recombinant IsaB rescued the virulence of the isaB deletion strain and increased the group A streptococcus (GAS) virulence in vivo. Together, these results reveal that IsaB diminishes autophagic flux, thereby allowing MRSA to evade host degradation. These findings suggest that IsaB is a suitable target for preventing or treating MRSA infection. 其他題名： J Invest Dermatol 出版者： United States: Elsevier Inc 出版日期： 2015-11-01 出處： Journal of investigative dermatology, 2015-11, Vol.135 (11), p.2714-2722 資源來源： Alma/SFX Local Collection 版權： 2015 The Society for Investigative Dermatology, Inc 版權： Copyright Nature Publishing Group Nov 2015 識別號： ISSN: 0022-202X 識別號： ISSN: 1523-1747 識別號： EISSN: 1523-1747 識別號： DOI: 10.1038/jid.2015.254 識別號： PMID: 26134948
