摘要： Acne vulgaris, a multi-factorial disease, is one of the most common skin diseases, affecting an estimated 80% of Americans at some point during their lives. The gram-positive and anaerobic Propionibacterium acnes ( P. acnes ) bacterium has been implicated in acne inflammation and pathogenesis. Therapies for acne vulgaris using antibiotics generally lack bacterial specificity, promote the generation of antibiotic-resistant bacterial strains, and cause adverse effects. Immunotherapy against P. acnes or its antigens (sialidase and CAMP factor) has been demonstrated to be effective in mice, attenuating P. acnes -induced inflammation; thus, this method may be applied to develop a potential vaccine targeting P. acnes for acne vulgaris treatment. This review summarizes reports describing the role of P. acnes in the pathogenesis of acne and various immunotherapy-based approaches targeting P. acnes, suggesting the potential effectiveness of immunotherapy for acne vulgaris as well as P. acnes -associated diseases. 其他題名： CDM 出版者： Netherlands: Bentham Science Publishers Ltd 出版日期： 2015-01-01 出處： Current Drug Metabolism, 2015-01, Vol.16 (4), p.245-254 識別號： ISSN: 1389-2002 識別號： ISSN: 1875-5453 識別號： EISSN: 1875-5453 識別號： DOI: 10.2174/1389200216666150812124801 識別號： PMID: 26264195
