| 摘要: | 摘要： Purpose: The premotor cortex plays a major role in motor planning and control, exhibiting hierarchical importance comparable to that of the primary motor cortex (M1). In this study, we compared the effects of cPMd modulation, which was achieved using inhibitory repetitive transcranial magnetic stimulation (rTMS), with those of contralesional M1 (cM1) modulation, to elucidate the roles of both regions on longitudinal motor recovery following a stroke. Methods: Forty-four patients who had sustained hemiplegia for 3 to 12 months were randomly allocated to a cPMd group, cM1 group, or sham group and received 10 sessions of 1-Hz rTMS. The Medical Research Council (MRC) Scale, Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), and a cortical excitability test were administered pre- and post- rTMS intervention. Results: cPMd modulation yielded significant improvements in MRC, FMA, and WMFT scores compared with sham stimulation and a significant effect on cortical excitability suppression equivalent to that of cM1 modulation, but engendered effects on motor improvement inferior to those of cM1 modulation. Conclusions: In patients with chronic stroke, the cPMd can fulfill a role similar to that of the cM1 in interhemispheric imbalance, which can be ameliorated by applying inhibitory rTMS to achieve substantial motor restoration.
其他題名： Restor Neurol Neurosci
出版者： London, England: SAGE Publications
出版日期： 2014
出處： Restorative neurology and neuroscience, 2014, Vol.32 (6), p.825-835
資源來源： EBSCOhost Academic Search Premier
版權： IOS Press. All rights reserved
識別號： ISSN: 0922-6028
識別號： ISSN: 1878-3627
識別號： EISSN: 1878-3627
識別號： DOI: 10.3233/RNN-140410
識別號： PMID: 25201815 |
