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| 題名: | Suppression of cardiac alternans by alternating-period-feedback stimulations |
| 作者: | 黎璧賢;Sridhar, S.;Le, Duy-Manh;Mi, Yun-Chieh;Sinha, Sitabhra;Lai, Pik-Yin;Chan, C. K. |
| 貢獻者: | 理學院物理學系 |
| 關鍵詞: | Algorithms;Animals;Biological Clocks - physiology;Feedback, Physiological - physiology;Female;Heart - physiology;Male;Models, Biological;Rats;Rats, Wistar |
| 日期: | 2013-04-15 |
| 上傳時間: | 2026-04-23 14:37:28 (UTC+8) |
| 出版者: | American Physical Society;United States |
| 摘要: | 摘要： Alternans response, comprising a sequence of alternating long and short action potential durations in heart tissue, seen during rapid periodic pacing can lead to conduction block resulting in potentially fatal cardiac failure. A method of pacing with feedback control is proposed to reduce the alternans and therefore the probability of subsequent cardiac failure. The reduction is achieved by feedback control using small perturbations of constant magnitude to the original, alternans-generating pacing period T, viz., using sequences of two alternating periods of T+ΔT and T-ΔT, with ΔT<<T. Such a control scheme for alternans suppression is demonstrated experimentally in isolated whole heart experiments. This alternans suppression scheme is further confirmed and investigated in detail by simulations of ion-channel-based cardiac models both for a single cell and in one-dimensional spatially extended systems. The mechanism of the success of our method can be understood in terms of dynamics in phase space, viz., as the state of activity of the cell being confined within a narrow volume of phase space for the duration of control, resulting in extremely diminished variation in successive action potential durations. Our method is much more robust to noise than previous alternans reduction techniques based on fixed point stabilization and should thus be more efficient in terms of experimental implementation, which has implications for clinical treatment for arrhythmia.
其他題名： Phys Rev E Stat Nonlin Soft Matter Phys
出版者： United States
出版日期： 2013-04
出處： Physical review. E, Statistical, nonlinear, and soft matter physics, 2013-04, Vol.87 (4), p.042712, Article 042712
識別號： ISSN: 1539-3755
識別號： ISSN: 1550-2376
識別號： EISSN: 1550-2376
識別號： DOI: 10.1103/PhysRevE.87.042712
識別號： PMID: 23679454 |
| 顯示於類別: | [物理學系] 期刊論文
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