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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/28339

    Title: Structure-Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle-Coumarin Conjugates
    Authors: Neyts,J;De Clercq,E;Singha,R;Chang,YH;Das,AR;Chakraborty,SK;Hong,SC;Tsay,SC;Hsu,MH;Hwu,JR
    Contributors: 中央大學
    Date: 2009
    Issue Date: 2010-06-29 19:46:28 (UTC+8)
    Publisher: 化學研究所
    Abstract: For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH2- linker were synthesized and found to possess significant antiviral activities. Prominent examples included imidazopyridine-coumarin 12c, purine-coumarin 12d, and benzoxazole-coumarin 14c, which inhibited HCV replication at an EC50 of 6.8, 2.0, and 12 mu M, respectively. The heteroatoms in bicycles
    Appears in Collections:[化學研究所] 期刊論文

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