Syntheses of acyclic analogs of didemnin B

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/28417

Title:	Syntheses of acyclic analogs of didemnin B
Authors:	Ramanjulu,JM;Joullie,MM;Li,WR
Contributors:	中央大學
Keywords:	CIS-TRANS ISOMERASE;CYCLOPHILIN;PROTEINS
Date:	1997
Issue Date:	2010-06-29 19:48:30 (UTC+8)
Publisher:	化學研究所
Abstract:	The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (1st) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine, D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.
Relation:	SYNTHETIC COMMUNICATIONS
Appears in Collections:	[Graduate Institute of Chemistry] journal & Dissertation

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