Syntheses of acyclic analogs of didemnin B

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题名:	Syntheses of acyclic analogs of didemnin B
作者:	Ramanjulu,JM;Joullie,MM;Li,WR
贡献者:	中央大學
关键词:	CIS-TRANS ISOMERASE;CYCLOPHILIN;PROTEINS
日期:	1997
上传时间:	2010-06-29 19:48:30 (UTC+8)
出版者:	化學研究所
摘要:	The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (1st) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine, D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.
關聯:	SYNTHETIC COMMUNICATIONS
显示于类别:	[化學研究所] 期刊論文

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