ent-Nabscessin A 及 Nabscessin B 之合成研究

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/76750

Title:	ent-Nabscessin A 及 Nabscessin B 之合成研究
Authors:	王偉益;Wang, WEI-YI
Contributors:	化學學系
Keywords:	肌醇;右旋樟腦;Nabscessin A;Nabscessin B;Nabscessin A;Nabscessin B;inositol;D-camphor
Date:	2018-08-22
Issue Date:	2018-08-31 11:35:17 (UTC+8)
Publisher:	國立中央大學
Abstract:	以肌醇(myo-inositol)作為起始物，與同時作為保護基及掌性輔助劑的右旋樟腦(D-camphor)反應得到單一的非鏡像異構物56，經由選擇性去氧、以疊氮化鈉(sodium azide)作為親核試劑進行SN2反應生成碳氮鍵、Staudinger還原反應等步驟，得到其關鍵中心脫氧胺基鯊肌醇(2-deoxy-scyllo-inosamine)此種結構，最後再經由一系列反應得到Nabscessin A及Nabscessin B。;Nabscessin A and Nabscessin B were prepared from commercial available myo-inositol. Treating myo-inositol with protective reagent D- camphor, serving as chiral auxiliary simultaneously, got the diastereomeric pure compound 56. Subsequent transformatios, including selective deoxygenation, amino group formation, etc, provided the key 2-deoxy-scyllo-inosamine core. Finally we completed the synthesis through a series of reaction.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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