脂質奈米顆粒在mRNA疫苗技術應用發展綜述;A review of technological developments in lipid nanoparticle application for mRNA vaccination

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Title:	脂質奈米顆粒在mRNA疫苗技術應用發展綜述;A review of technological developments in lipid nanoparticle application for mRNA vaccination
Authors:	葉咨甫;FU, YEH TZU
Contributors:	跨領域轉譯醫學研究所
Keywords:	脂質奈米顆粒;mRNA 疫苗;COVID-19;期刊分析;專利分析;生物醫藥專利;Lipid Nanoparticle (LNP);mRNA vaccine;COVID-19;journal analysis;patent analysis;biomedical patents
Date:	2024-01-29
Issue Date:	2024-09-19 16:41:50 (UTC+8)
Publisher:	國立中央大學
Abstract:	本研究深入探討了脂質納米粒子（LNP）技術在mRNA領域的專利格局，並分析了其在生物醫學領域的技術創新。研究旨在揭示技術創新是否遵循技術線性模型，同時深入研究核心技術團隊、關鍵專利以及相關疫苗專利的發展。過往研究對於LNP技術和mRNA疫苗的專利格局及專利糾紛關注不足，本研究填補了這一空白。我們透過文獻引用分析、專利分析、專利訴訟案例研究等多元方法，詳細梳理了LNP技術的專利現狀，並探討了專利叢林對技術創新的影響及專利豁免政策的實際效果。本研究發現，LNP技術在mRNA疫苗開發中發揮了關鍵作用，其創新過程符合技術線性模型。研究還指出，專利格局及市場競爭格局中，賓州大學和麻省理工學院等學術機構在基礎研究上作出了顯著貢獻，而Moderna、BioNTech等公司在專利申請和市場競爭中佔有重要地位。此外，專利叢林現象和專利訴訟案例顯示，專利權的行使可能對技術創新和公共衛生利益產生重大影響。綜上所述，本研究不僅深入分析了LNP技術在mRNA領域的專利狀況，還探討了專利政策對技術創新和公共衛生的複雜影響，為相關利益者提供了寶貴的見解和策略建議，有助於促進技術創新並維護公共利益。;This study delves into the patent landscape of Lipid Nanoparticle (LNP) technology in the mRNA field and analyzes its technological innovation in the biomedical domain. It aims to reveal whether technological innovation follows the linear model of technology and examines in-depth the core technical teams, key patents, and the development of related vaccine patents.Previous research has inadequately focused on the patent landscape and disputes concerning LNP technology and mRNA vaccines. This study fills this gap. Employing diverse methodologies such as literature citation analysis, patent analysis, and case studies of patent litigation, we comprehensively outline the current patent status of LNP technology and discuss the impact of patent thickets on technological innovation, along with the practical effects of patent exemption policies. Our findings indicate that LNP technology plays a pivotal role in the development of mRNA vaccines, aligning with the linear model of technology innovation. The study also identifies significant contributions of academic institutions such as the University of Pennsylvania and MIT in basic research, while companies like Moderna and BioNTech hold significant positions in patent applications and market competition. Furthermore, phenomena like patent thickets and cases of patent litigation suggest that the exercise of patent rights can significantly impact technological innovation and public health interests. In summary, this research not only analyzes in depth the patent status of LNP technology in the mRNA field but also explores the complex impact of patent policies on technological innovation and public health. It provides valuable insights and strategic recommendations for stakeholders, aiding in the promotion of technological innovation and the safeguarding of public interests.
Appears in Collections:	[Graduate Institute of Translational Interdiscplinary] Electronic Thesis & Dissertation

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