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https://ir.lib.ncu.edu.tw/handle/987654321/97562
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| 題名: | 設計與合成應用於硫化氫檢測的1,2,3-三嗪螢光響應探針;Design and Synthesis of 1,2,3-Triazine-based Fluorogenic Probes for Hydrogen Sulfide Detection |
| 作者: | 許喆俞;Hsu, Che-Yu |
| 貢獻者: | 化學學系 |
| 關鍵詞: | 硫化氫檢測;螢光探針;1,2,3-三嗪;二氟化硼二吡咯亞甲基;hydrogen sulfide detection;fluorogenic probes;1,2,3-triazine;BODIPY |
| 日期: | 2025-08-20 |
| 上傳時間: | 2025-10-17 11:36:55 (UTC+8) |
| 出版者: | 國立中央大學 |
| 摘要: | 最近的研究表明，硫化氫生成酶在癌細胞中選擇性過度表達，導致細胞內硫化氫濃度高於正常細胞。這一現象顯示硫化氫有可能作為區分癌細胞和正常細胞的生物標記。本研究中，我們設計並合成了一系列基於1,2,3-三嗪的螢光探針用於檢測硫化氫，這些探針利用1,2,3-三嗪作為螢光猝滅劑，並與硫化氫反應，重啟發光團BODIPY基團的螢光放射。在一系列合成的三嗪螢光響應探針: 3-Tz-H、3-Tz-Et、8-Tz-H及8-Tz-Et與硫化鈉反應後，產生明顯的螢光強度差異，表明它們對硫化氫具有有效的反應。這些結果表明，基於1,2,3-三嗪設計的螢光探針有望用於檢測癌細胞中的硫化氫的潛力。;Recent studies have indicated that the hydrogen sulfide-producing enzymes are selectively overexpressed in cancer cells, resulting in elevated intracellular H2S concentrations compared to those in normal cells. This phenomenon suggests that H₂S has the potential to serve as a biomarker for distinguishing cancer cells from their normal counterparts. In this study, we designed and synthesized a series of 1,2,3-triazine-based fluorogenic probes for H2S detection. These probes utilize 1,2,3-triazine as a fluorescence quencher, which reacts with H2S to trigger the emission of the fluorophore BODIPY. Among the synthesized probes, 3-Tz-H, 3-Tz-Et, 8-Tz-H, and 8-Tz-Et exhibited significant fluorescence enhancement upon reaction with sodium sulfide, indicating an effective response to H2S. These findings suggest that 1,2,3-triazine-based fluorogenic probes hold promise for detecting H2S in cancer cells. |
| 顯示於類別: | [化學研究所] 博碩士論文
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