全場光強差動式表面電漿共振偵測技術

以作者查詢圖書館館藏

、以作者查詢臺灣博碩士

、以作者查詢全國書目

、勘誤回報

、線上人數：34

、訪客IP：3.142.197.198

姓名

古武昇(Wu-Sheng Gu) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

全場光強差動式表面電漿共振偵測技術
(Intensity differential surface plasmon resonance technique with full-field detection)

相關論文

★ 外差光學式光柵干涉儀之研究	★ 以二維影像重建三維彩色模型之色彩紋理貼圖技術與三維模型重建系統發展
★ 雷射干涉儀於共焦顯微系統之軸向定位控制	★ 偏振干涉術使用在量測旋光效應及葡萄糖濃度
★ 準共光程干涉術之新式大尺度定位平台之研究	★ 波長調制外差散斑干涉術應用於角度量測之研究
★ 基於全內反射波長調制外差干涉術小角度測量	★ 新型波長調制外差光源應用於位移量測
★ 疊紋式自動準直儀系統	★ 雙影像多視角結構光轉三維點資料技術發展
★ 偏振式駐波干涉儀應用於位移量測	★ 雙共焦顯微鏡用於物體厚度量測
★ 以電漿診斷工具進行太陽電池用矽薄膜製程開發	★ 基於全反射共光程偏振干涉術之折射率量測技術
★ 點繞射干涉儀應用於透鏡之像差量測	★ Gioia 和 Chakraborty 紊流摩擦係數模型之研究

檔案

[Endnote RIS 格式]

[Bibtex 格式]

[相關文章]

[文章引用]

[完整記錄]

[館藏目錄]

[檢視]

[下載]

本電子論文使用權限為同意立即開放。
已達開放權限電子全文僅授權使用者為學術研究之目的，進行個人非營利性質之檢索、閱讀、列印。
請遵守中華民國著作權法之相關規定，切勿任意重製、散佈、改作、轉貼、播送，以免觸法。

摘要(中)

本論文以差動偵測技術配合表面電漿共振技術，再結合CCD擷取影像資訊，提出一套可偵測一平面折射率分布的「全場光強差動式表面電漿共振偵測技術」。本研究利用差動偵測的概念，除了可有效消除光源強度浮動和背景光雜訊對訊號的影響外，並且可提升共振光強分析式系統對於折射率的靈敏度，以改善一般光強分析式系統的缺點。
對於實驗結果作分析後，可得知本系統光強差動訊號對於折射率的靈敏度為1.35×10^2 (1/RIU)，而光強差動訊號之解析度為0.0016，由前面兩者可算出本系統對於折射率的解析度為1.2×10^-5 RIU。本系統具有成本低、即時量測、靈敏度和解析度高的優點，若能實際將此技術使用於生物分子陣列晶片的偵測，對於生醫檢測領域將是一大貢獻。

摘要(英)

An intensity differential surface plasmon resonance (SPR) technique with full-field detection is proposed. In this study, we combine the differential detection technique, SPR technique and CCD camera to detect the refractive index variation of the testing sample. The system can not only reduce the influence of laser source fluctuation and ambient noise, but also improve the measurement sensitivity and resolution, to improve the defect of common resonance light intensity.
The experimental results demonstrate that the sensitivity of the system is 1.35×10^2 (1/RIU) and the resolution of intensity differential signal is 0.0016, so the resolution of refractive index is 1.2×10^-5 RIU. The system has the advantages of low cost, real-time detection, higher sensitivity and resolution. If the system can be applied to the biological molecule array, it will have large contribution for biomedical testing.

關鍵字(中)

★ 全場光強
★ 差動偵測
★ 表面電漿共振

關鍵字(英)

★ full-field detection
★ differential detection
★ surface plasmon resonance

論文目次

摘要i
Abstractii
誌謝iii
目錄iv
圖目錄vi
表目錄viii
第一章緒論1
1-1 研究背景1
1-2 文獻回顧1
1-3 研究動機、目的與方法7
1-4 論文架構8
第二章基礎理論9
2-1 表面電漿共振原理9
2-1-1 表面電漿共振理論推導9
2-1-2 激發表面電漿波的方式11
2-1-3 Kretschmann架構下的光強反射率推導13
2-2 反射光強差動偵測原理18
2-3 小結21
第三章實驗架構22
3-1 感測器參數設計 22
3-2 感測器機構設計 25
3-3 整體系統架構30
3-4 程式設計33
3-4-1 第一部分：角度掃描33
3-4-2 第二部分：光強差動訊號擷取35
3-5 小結37
第四章結果與討論38
4-1 實驗準備38
4-1-1 製作表面電漿共振感測器38
4-1-2 待測物42
4-1-3 全場量測感測片42
4-2 第一部分實驗：單點量測43
4-2-1 交叉通入氣體實驗44
4-2-2 階梯通入氣體實驗48
4-3 第二部分實驗：全場量測49
4-4 第三部分實驗：消除光源強度浮動實驗56
4-5 系統對折射率之解析度分析60
4-5-1 光強差動訊號之解析度60
4-5-2 系統對於折射率之靈敏度60
4-5-3 系統對於折射率之解析度61
4-6 系統誤差分析61
4-6-1 共振角誤差61
4-6-2 光強差動訊號誤差62
4-7 小結63
第五章結論與未來展望64
參考文獻 65

參考文獻

[1].安毓英、曾小東，光學感測與量測，五南圖書，台北市，2004年。
[2].T. Velinov, L. Ahtapodov, A. Nelson, M. Gateshki and M. Bivolarska, “Influence of the surface roughness on the properties of Au films measured by surface plasmon resonance and X-ray reflectometry”, Thin Solid Films, Vol. 519, No. 7, pp. 2093-2097, 2011.
[3].L. K. Chau, Y. F. Lin, S. F. Cheng and T. J. Lin, “Fiber-optic chemical and biochemical probes based on localized surface plasmon resonance”, Sensors and Actuators, Vol. 113, No. 1, pp. 100-105, 2006.
[4].B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman and R. M. Corn, “Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays”, Analytical Chemistry, Vol. 73, No. 1, pp. 1-7, 2001.
[5].S.Y. Rabbany, W. J. Lane, W. A. Marganski, A. W. Kusterbeck and F. S. Ligler, “Trace detection of explosives using a membrane-based displacement immunoassay”, Journal of Immunological Methods, Vol. 246, No. 1-2, pp. 69-77, 2000.
[6].J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor and J. Scrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide”, Sensors and Actuators, Vol. 76, No. 1-3, pp. 8-12, 2001.
[7].R. Karamanska, J. Clarke, O. Blixt, J. I. MacRae, J. Q. Zhang, P. R. Crocker, N. Laurent, A. Wright, S. L. Flitsch, D. A. Russell and R. A. Field, “Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays”, Glycoconjugate Journal, Vol.25, No. 1, pp. 69-74, 2008.
[8].K. M. Mayer, S. Lee, H. Liao, B. C. Rostro, A. Fuentes, P. T. Scully, C. L. Nehl and J. H. Hafner, “A label-free immunoassay based upon localized surface plasmon resonance of gold nanorods” Acs Nano, Vol. 2, No. 4, pp. 687-692, 2008.
[9].B. Sepulveda, A. Calle, L. M. Lechuga and G. Armelles, “Highly sensitive detection of biomolecules with the magneto-optic surface-plasmon-resonance sensor”, Optics Letters, Vol. 31, No. 8, pp. 1085-1087, 2006.
[10].M. Piliarik, H. Vaisocherova and J. Homola, “A new surface plasmon resonance sensor for high-throughput screening applications”, Biosensors and Bioelectronics, Vol. 20, No. 10, pp. 2104-2110, 2005.
[11].R. L. Rich and D. G. Myszka, “Advances in surface plasmon resonance biosensor analysis”, Current Opinion in Biotechnology, Vol. 11, No. 1, pp. 54-61, 2000.
[12].D. Kitenge, R. K. Joshi, M. Hirai and A. Kumar, “Nanostructured silver films for surface plasmon resonance-based gas sensors”, IEEE Sensors Journal, Vol. 9, No. 12, pp. 1797-1801, 2009.
[13].R. W. Wood, “On a remarkable case of uneven distribution of light in a diffraction grating spectrum”, Philosophical Magazine Series 6, Vol. 4, No. 21, pp. 396-402, 1902.
[14].Sommerfeld, “Uber die Ausbreitung der Wellen in der drahtlosen Telegraphie”, Annalen der Physik, Vol. 333, No. 4, pp. 665-736, 1909.
[15].E. Rudberg, N. Institute, Stockholm, Sweden, “Energy losses of electrons in nitrogen”, Proceedings of the Royal Society of London, Vol. 129, No. 811, pp. 628-651, 1930.
[16].U. Fano, “The theory of anomalous diffraction gratings and of quasi-stationary waves on metallic surfaces (Sommerfeld’’s Waves)”, Journal of the Optical Society of America, Vol. 31, No. 3, pp. 213-222, 1941.
[17].A. Otto, “Excitation of nonradiative surface plasma waves in silver by method of frustrated total reflection”, Zeitschrift fur physik, Vol.216, No.4, pp. 398–410, 1968.
[18].E. Kretschmann, et al., “Decay of non radiative surface plasmons into light on rough silver films. Comparison of experimental and theoretical results”, Optics Communications, Vol. 6, No. 2, pp. 185-187, 1972.
[19].C. Nylander, B. Liederg and T. Lind, ”Gas detection by means of surface plasmon resonance”, Sensor and Actuators, Vol. 3, No. 1, pp. 79-88, 1982.
[20].B. Liedberg, C. Nylander and I. Lundstorm, “Surface plasmon resonance for gas detection and biosensing”, Sensors and Actuators 4, pp. Vol. 4, No. 2, pp. 299-304, 1983.
[21].S. F. Wang, M. H. Chiu, C. W. Lai and R. S. Chang, “High-sensitivity small-angle sensor based on surface plasmon resonance technology and heterodyne interferometry”, Applied Optics, Vol. 45, No. 26, pp. 6702-6707, 2006.
[22].M. Nakkach, P. Lecaruyer, F. Bardin, J. Sakly, Z. B. Lakhdar and M. Canva, “Absorption and related optical dispersion effects on the spectral response of a surface plasmon resonance sensor”, Applied Optics, Vol. 47, No. 33, pp. 6177-6182, 2008.
[23].B. Chadwick and M. Gal, “An optical temperature sensor using surface plasmons”, Japanese Journal Of Applied Physics Part 1-Regular Papers Short Notes & Review Papers, Vol. 32, No. 6A, pp. 2716-2717, 1993.
[24].S. Shen, T. Liu and J. Guo, “Optical phase-shift detection of surface plasmon resonance”, Applied Optics, Vol. 37, No. 10, pp. 1747-1751, 1998.
[25].S. G. Nelson, K. S. Johnston and S. S. Yee, “High sensitivity surface plasmon resonance sensor based on phase detection”, Sensors and Actuators B-Chemical, Vol. 35, No. 1, pp. 187-191, 1996.
[26].H. Nakajima, Y. Harada, Y. Asano, T. Nakagama, K. Uchiyama, T. Imato, N. Soh and A. Hemmi, “A palm-sized surface plasmon resonance sensor with microchip flow cell”, Talanta, Vol. 70, No. 2, pp. 419-425, 2006.
[27].E. S. Forzani, H. Zhang, W. Chen and N. Tao, “Detection of heavy metal ions in drinking water using a high-resolution differential surface plasmon resonance sensor”, Environmental Science & Technology, Vol. 39, No. 5, pp. 1257-1262, 2005.
[28].M. Naya, N. Mori, T. Kimura, H. Ohtsuka, T. Kubo and H. Shimizu, “Extremely high signal-to-noise ratio surface plasmon resonance sensor using a monolithic prism sensor chip”, Journal of Nanophotonics, Vol. 1, pp. 011596, 2007.
[29].H. Suzuki, M. Sugimoto, Y. Matsui and J. Kondoh, “Development of a dual-color optical fiber SPR sensor”, Sensors, 2005 IEEE, pp. 865-868, 2005.
[30].A. Zybin, C. Grunwald, V. M. Mirsky, J. Kuhlmann, O. S. Wolfbeis and K. Niemax, “Double-wavelength technique for surface plasmon resonance measurements: Basic concept and applications for single sensors and two-dimensional sensor arrays”, Analytical Chemistry, Vol. 77, No. 8, pp. 2393-2399, 2005.
[31].J. Y. Lee and S. K. Tsai, “Measurement of refractive index variation of liquids by surface plasmon resonance and wavelength-modulated heterodyne interferometry”, Optics Communications, Vol. 284, No. 4, pp. 925-929, 2011.
[32].S. Y. Wu, H. P. Ho, W. C. Law and C. Lin, “Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration”, Optics Letters, Vol. 29, No. 20, pp. 2378-2380, 2004.
[33].C. M. Wu and M. C. Pao, “Sensitivity-tunable optical sensors based on surface plasmon resonance and phase detection”, Optics Express, Vol. 12, No. 15, pp. 3509-3514, 2004.
[34].H. P Chiang, H. T. Yeh, C. M. Chen, J. C. Wu, S. Y. Su, R. Chang, Y. J. Wu, D. P. Tsai, S. U. Jen and P. T. Leung, “Surface plasmon resonance monitoring of temperature via phase measurement”, Optics Communications, Vol. 241, No. 4-6, pp. 409-418, 2004.
[35].吳民耀和劉威志，「表面電漿子理論與模擬」，物理雙月刊，第二十八卷，第二期，486~496頁，2006年。
[36].蔡欣凱，「波長調制旋光外差干涉術應用於表面電漿共振偵測」，中央大學，碩士論文，2010年。
[37].J. Davies, L. R. Fisher and A. D. Mello, Surface analytical techniques for probing biomaterial processes, CRC, 1996.
[38].周登科，「全場相位式表面電漿共振生醫感測器」，中央大學，碩士論文，2007年。

指導教授

李朱育(Ju-Yi Lee)

審核日期

2012-1-20

推文