Free energy and critical force for adhesion clusters

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/50946

Title:	Free energy and critical force for adhesion clusters
Authors:	Lin,HJ;Chen,HY;Sheng,YJ;Tsao,HK
Contributors:	生物物理研究所
Keywords:	CHEMICAL-REACTIONS;BONDS;SPECTROSCOPY;STRENGTH;RUPTURE;FIELD
Date:	2010
Issue Date:	2012-03-27 18:13:27 (UTC+8)
Publisher:	國立中央大學
Abstract:	Cooperative clusters of N parallel bonds confined to an anchoring surface by springs of stiffness k(s) are considered. The free energy of a cluster can be obtained from its force-displacement relation. The dissociation kinetics of the cluster can be modeled as the dissociation of an effective single bond. There is a critical force F(c) beyond which the barrier for the cluster dissociation vanishes. F(c) scales such as k(s)(1/2) and F(c)/N is small compared to the critical force of a single bond. The theoretical predictions of free energy landscape and cluster lifetime are supported by numerical simulations for large number of bonds. Our study suggests that experiments measuring force-displacement relations could be useful in exploring the dynamics of adhesion clusters.
Relation:	PHYSICAL REVIEW E
Appears in Collections:	[Graduate Institute of Biophysics] journal & Dissertation

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