Free energy and critical force for adhesion clusters

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题名:	Free energy and critical force for adhesion clusters
作者:	Lin,HJ;Chen,HY;Sheng,YJ;Tsao,HK
贡献者:	生物物理研究所
关键词:	CHEMICAL-REACTIONS;BONDS;SPECTROSCOPY;STRENGTH;RUPTURE;FIELD
日期:	2010
上传时间:	2012-03-27 18:13:27 (UTC+8)
出版者:	國立中央大學
摘要:	Cooperative clusters of N parallel bonds confined to an anchoring surface by springs of stiffness k(s) are considered. The free energy of a cluster can be obtained from its force-displacement relation. The dissociation kinetics of the cluster can be modeled as the dissociation of an effective single bond. There is a critical force F(c) beyond which the barrier for the cluster dissociation vanishes. F(c) scales such as k(s)(1/2) and F(c)/N is small compared to the critical force of a single bond. The theoretical predictions of free energy landscape and cluster lifetime are supported by numerical simulations for large number of bonds. Our study suggests that experiments measuring force-displacement relations could be useful in exploring the dynamics of adhesion clusters.
關聯:	PHYSICAL REVIEW E
显示于类别:	[生物物理研究所 ] 期刊論文

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