English  |  正體中文  |  简体中文  |  Items with full text/Total items : 75533/75533 (100%)
Visitors : 27275658      Online Users : 479
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/65051

    Title: 黑色素的奈米化大幅提升其用在保護細胞對抗活性氧壓力的效用;Dramatic Improvement of the Efficacy of Melanin on Protecting Cells against ROS Stress by Its Nanonization
    Authors: 陳思旻;Chen,Sih-min
    Contributors: 生物物理研究所
    Keywords: 黑色素;奈米薄片;水分散性;活性氧;自由基;氧化壓力;急性輻射綜合症;melanin;nano-flake;water-dispersible;reactive oxygen species;free radical;oxidative stress;acute radiation syndrome
    Date: 2014-08-28
    Issue Date: 2014-10-15 14:39:05 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 目的:黑色素是已知具有清除自由基及活性氧的能力。本論文提出利用奈米化黑色素作為藥物來對抗內源性氧化壓力或外源性急性氧化壓力,例如:急性輻射綜合症。


    結果與討論:機械式攪拌可以有效奈米化黑色素。在視網膜色素上皮細胞暴露在外源性活性氧壓力下,奈米化黑色素相較於未處理的黑色素明顯有效提高存活率。這個結果在不照光時有更明顯的提升,有希望應用於靜脈給藥的體內試驗。;Aim: It is known that melanin has the ability of scavenging free radicals and reactive oxygen species (ROS). The authors propose to utilize nanonized melanin as medication against endogenous chronic oxidative stress or exogenous acute oxidative stress caused by, e.g., acute radiation exposure.

    Materials & Methods: A simple technique based on mechanical stir was developed for nanonization of melanin to produce nanometer-sized and water-dispersible melanin. The viabilities of cultured retinal pigment epithelium (RPE) cells exposed to exogenous H2O2 stress and treated with various conditions of melanin and irradiation were compared.

    Results & Conclusion: Melanin can be nanonized very effectively with simple mechanical stir. Nanonized melanin exhibited a much stronger effect than unprocessed melanin on raising the viability of cultured RPE cells under exogenous acute ROS stress. The effect was even more prominent without simultaneous light irradiation, promising for effective in vivo application to the whole body via intravenous administration.
    Appears in Collections:[生物物理研究所 ] 博碩士論文

    Files in This Item:

    File Description SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 隱私權政策聲明