Nabscessin C (1)是由市售的肌醇(myo-inositol)與原乙酸三乙酯(triethyl orthoacetate)經由13步合成出來。此合成的特點為利用肌醇(myo-inositol)原有的六員環架構，將環上羥基進行去氧(deoxygenation)，以豬胰脂肪酶(porcine pancreas lipase)作為催化劑對內消旋(meso)化合物 89進行去對稱化反應 (desymmetrization)，經還原胺化反應(reductive amination)，得到其關鍵的2-脫氧胺基鯊肌醇(2-deoxy-scyllo-inosamine, DOIA)核心結構，再藉由後續一系列反應合成目標產物。;Nabscessin C was synthesized from commercially available myo-inositol and triethyl orthoacetate in 13 steps.This synthesis started from myo-inositol and subsequent transformations, including deoxygenation, desymmtrization of meso compound 89 by procine pancreas lipase and reductive amination, provided the key 2-deoxy-scyllo-inosamine core (DOIA). This core was then transformed into the target product through a series of subsequent reactions.
