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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/28417

    Title: Syntheses of acyclic analogs of didemnin B
    Authors: Ramanjulu,JM;Joullie,MM;Li,WR
    Contributors: 中央大學
    Date: 1997
    Issue Date: 2010-06-29 19:48:30 (UTC+8)
    Publisher: 化學研究所
    Abstract: The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (1st) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine, D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.
    Appears in Collections:[化學研究所] 期刊論文

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