This project will bring significant outcomes in terms of innovations: a craniotomy robot using collaborative method is proposed for the first time. A new intra-operative registration method using classical navigation system will represent significant time-saving. The completion of the present project will bring valuable academic outcomes in the field of mechanism science. Through the high reconfigurability of the proposed mechanism, a variety of performance can be optimized for other type of applications. Indeed, the robotization of several medical applications (such as tele-echography or MIS) requires RCM manipulators. Therefore, the resulting mechanism prototypes will have the potential to serve as the base of new robotic manipulators for medical applications. The growing local industry in robotics could have interest in the enhanced performance, higher flexibility, expected reduced weight, size and possibly cost of these manipulators. Especially companies which develop medical robots such as HIWIN, Brain Navi, Point Robotics or medical technologies such as Adronic, Chang Gung Medical Technology, etc. could have high interest in such an endeavor.